摘要
目的探讨老年慢性阻塞性肺疾病急性加重期(AECOPD)治疗前后D-二聚体变化及临床意义。方法随机选取40例老年慢性阻塞性肺疾病急性加重期患者,检测治疗前后血清D-二聚体含量,选取40名健康体检者为对照组。同时测定老年AECOPD治疗前患者动脉血氧分压,分析血清D-二聚体水平与动脉血氧分压的相关性。结果老年AECOPD患者在治疗前后血清D-二聚体含量均较对照组升高,差异有统计学意义(P<0.05)。老年AECOPD患者在治疗后较治疗前D-二聚体含量明显减少,差异有统计学意义(P<0.05)。老年AECOPD患者血清D-二聚体水平与动脉血氧分压呈负相关(P<0.05)。结论 COPD患者存在血栓前状态,D-二聚体水平可能反映COPD患者病情的严重程度及凝血功能状态。
Objective To investigate the clinical significance of changes of serum D-dimer tor the elderly pataents with a- cute exacerbation of chronic obstructive pulmonary disease （AECOPD）before and after treatment. Methods 40 elderly patients with AECOPD were randomly selected ,The serum D-dimer level of these 40 subjects were determined before and after treatment. 40 healthy persons were selected for the healthy control group. The arterial Pa02 was detected for the elderly patients with AECOPDbefore treatment. The association between serum D-dimer and PaO2 was analyzed. Results The serum D-dimer level in AECOPD group was higher than the control group. The difference was considered significant（P 〈 0.05）. The serum D-dimer level with elderly AECOPD patients after treatment was lower than those before treatment （P 〈 0. 05 ）. Serum D-dimer level was negatively correlated with PaO 2 （P 〈 0. 05）. Conclusion The prothrombotic state probably exists in COPD patients. Serum D-dimer level might reflect the severity of COPD and coagulation status.
出处
《四川医学》
CAS
2015年第5期681-683,共3页
Sichuan Medical Journal
