摘要
目的探讨慢性阻塞性疾病急性加重期(AECOPD)患者D-二聚体(D-D)水平在预测患者预后中的作用。方法选择2008年7月至2010年12月期间该院收治的AECOPD患者99例为研究对象,根据患者D-D表达是否表达阳性(截断值500μg/L)将其分为观察组(n=50)和对照组(n=49),调查2组患者的住院基本信息及生存情况,并采用散射光比浊法检测患者血浆D-D水平,采用受试者工作特征曲线(ROC)评价D-D对患者生存状况的预测价值,采用Kaplan-Meier比较2组研究对象的生存时间。结果不同性别、年龄、GOLD评级的患者之间D-D水平差异无统计学意义(P>0.05);观察组D-D水平、首次住院时间、再次住院次数、首次住院病死率及再次住院病死率均显著高于对照组(P<0.05);ROC曲线显示,D-D水平预测患者近期及远期死亡的截断值分别为1 171.34、893μg/L;观察组、对照组患者平均生存时间分别为30.37、46.37个月;Kaplan-Meier显示观察组患者的生存时间显著低于对照组(χ2=6.371,P<0.05)。结论 AECOPD患者D-D水平对预测患者近期、远期的预后结局具有重要的价值,其可作为反映患者疾病进展的一个独立指标。
Objective To explore the role of D-dimer（D-D）level in patients with acute exacerbation of chronic obstructive disease（AECOPD）in predicting the prognosis of patients.Methods 99 patients with AECOPD in our hospital from July 2008 to December 2010 were selected as the subjects,and were divided into observation group（n=50）and control group（n=49）according to the expression of D-D in patients with positive（D-D level cutoff value of 500 g/L）.The basic information and survival of the two groups of patients were investigated,and the level of serum D-D was detected by scatter turbidimetry.The receiver operating characteristic curve（ROC）was used to evaluate the predictive value of D-D on the survival of the patients.The survival time of the two groups was compared by Kaplan-Meier.Results There was no statistically significant difference in gender,age and GOLD score between the two groups（P〈0.05）.The level of D-D,the time of first hospitalization,the number of re hospitalization,the first hospital mortality and re hospitalization mortality in the observation group were significantly higher than those in the control group（P〉0.05）.The ROC curve showed that the truncated value of D-D was 1 171.34 g/L and 893 g/L,respectively.The average survival time of patients in the observation group was 30.37 months and the control group was 46.37 months,respectively;Kaplan-Meier study showed that the survival time of patients in the observation group was significantly lower than that in the control group（χ2=6.371,P〈0.05）.Conclusion The level of D-D in patients with AECOPD is of great value in predicting the prognosis of patients,which can be used as an independent indicator of disease progression.
出处
《国际检验医学杂志》
CAS
2018年第5期596-598,共3页
International Journal of Laboratory Medicine
