摘要
目的分析超敏C-反应蛋白(hs-CRP)在老年慢性阻塞性肺疾病急性加重期(AECOPD)合并2型糖尿病(T2DM)患者中的含量,探讨其在老年AECOPD合并T2DM患者中的变化及临床意义。方法选取50例老年AECOPD合并T2DM患者和50例老年AECOPD患者,分别检测两组hs-CRP、氧分压(PO2)、中性粒细胞百分比(NE%)、白细胞计数(WBC)、红细胞沉降率(ESR)的含量。结果 AECOPD合并T2DM组hs-CRP、NE%高于AECOPD组(P<0.01,P<0.05),PO2低于AECOPD组(P<0.01),WBC、ESR两组相比差异无统计学意义。AECOPD合并T2DM组hs-CRP、NE%、WBC、ESR阳性率高于AECOPD组(P<0.01,P<0.05,P<0.05,P<0.05)。AECOPD合并T2DM组hs-CRP和NE%、WBC、ESR呈正相关(P<0.01,P<0.05,P<0.05)。结论 hs-CRP的升高可能与T2DM加重了老年AE-COPD患者的炎症作用有关。
Objective To analyze the content of high sensitive C-reactive protein（hs-CRP） in elderly patients with chronic obstructive pulmonary disease in acute exacerbation period（AECOPD） combined with type 2 diabetes mellitus（T2DM） , and to explore the relationship between the variation of hs-CRP and clinical significance in the elderly patients suffering from AECOPD with underlying T2DM. Methods 50 cases of elderly patients suffering from AECOPD with T2DM and 50 elderly patients suffering from AECOPD were selected, and the hs-CRP, partial pressure of oxygen （ PO2 ）, neuter granuloeyte percentage （ NE% ）, white blood ceil count （ WBC）, and erythrocyte sedimentation rate（ESR）were detected. Results hs-CRP and NE% in the group of AECOPD with T2DM were higher than those in AECOPD group （P 〈 0.01, P 〈 0.05 ）, and the PO2 was lower than in AECOPD group （P 〈 0.01 ）, there was no significant difference on WBC and ESR between the two groups. The positive rates of hs-CRP,NE% ,WBC and ESR in AECOPD combined with T2DM group were higher than those in AECOPD group（P 〈0.01 ,P 〈0. 05, P 〈0.05 ,P 〈0.05）. Hs-CRP was positively correlated with NE% ,WBC,ESR in AECOPD combined with T2DM group （P 〈 0.01 ,P 〈 0.05, P 〈 0. 05）. Conclusion The elevation of hs-CRP may be associated with aggravation of inflammation of T2DM in the elderly patients with AECOPD.
出处
《安徽医科大学学报》
CAS
北大核心
2013年第6期643-646,共4页
Acta Universitatis Medicinalis Anhui
关键词
慢性阻塞性肺疾病
急性加重
2型糖尿病
超敏C-反应蛋白
chronic obstructive pulmonary disease
acute exacerbation
type 2 diabetes mellitus
high sensitivity C-reactive protein
