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半胱氨酸蛋白酶抑制剂Stefins的功能研究进展 被引量：3

Advances in biological function of stefins
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摘要 Stefins是半胱氨酸蛋白酶抑制剂超家族(Cystatins)的一个分支,属于Ⅰ型Cystatins,在人类中主要包括Stefin A和Stefin B。Stefins具有多种生物学功能:Stefin B的基因突变与翁-隆病(Unverricht-Lundborg disease,EPM1)的发生紧密相关;Stefins参与淀粉斑的形成,在阿尔茨海默病的发生、发展中发挥重要作用;近年来关于Stefins在肿瘤的发生、发展、侵袭、转移中的作用备受关注。本文就Stefins的功能研究进展作一综述。 Stefins family is a branch of cystatin superfamily, which apparently acts as inhibitors of cysteine proteases, belonging to type I cystatins. Stefin A and stefin B are the main two kinds of stefins in human beings. Stefins has many biological functions： the gene mutation of stefin B is closely related to the development of Unverricht-Lundborg disease （EPM1）; Stefin A and stefin B participate in the formation of the amyloid plaque, which play an important role in the development of Alzheimer＇s disease; Stefins may also involve in the genesis, development, invasion and metastasis of tumor. This review elucidates the advances in biological function of stefins.
作者 刘彪 范奇超 林扬元 谢群
机构地区 莆田学院临床医学院 莆田学院基础医学部
出处 《解放军医学院学报》 CAS 2015年第5期518-520,524,共4页 Academic Journal of Chinese PLA Medical School
基金 国家自然科学基金资助项目(81201670) 福建省中青年教师教育科研项目(JA13287 JB11168) 福建省教育厅资助省属高校科研专项(JK2011050) 莆田市科技计划项目[2012S11(1)] 国家级大学生创新创业训练计划项目(201411498007)~~
关键词 Stefins 翁-隆病 阿尔茨海默病 肿瘤 stefins Unverricht-Lundborg disease Alzheimer disease neoplasms
分类号 R730 [医药卫生—肿瘤] R338 [医药卫生—人体生理学]
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参考文献33

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二级参考文献20

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解放军医学院学报
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