摘要
目的探讨乳腺浸润性导管癌磁共振扩散加权成像表观扩散系数(DWI-ADC)与乳腺浸润性导管癌预后指标之间的相关性。资料与方法经手术病理确诊的103例乳腺浸润性导管癌患者行DWI扫描(b=1000 s/mm2),测定病灶的最小ADC值。病灶切除后取相应标本,记录肿瘤传统预后因子(肿瘤大小、淋巴结转移状态、病理分级)及生物学预后因子(Ki-67、To Po-IIα、P53和Cyclin D1)的表达情况,并与病灶的ADC值进行相关性分析。结果所有患者传统预后因子和生物学预后因子病灶的平均ADC值组内差异均无统计学意义(P>0.05)。所有患者病灶内平均ADC值与传统预后因子和生物学预后因子的表达均无相关性(P>0.05)。肿瘤病理分级与生物学预后因子Ki-67、To Po-IIα表达水平呈正相关(P<0.05)。结论乳腺浸润性导管癌的ADC值尚不能指导其预后的评估,然而生物学预后因子Ki-67和To PoIIα在乳腺癌中的表达水平对评估患者预后和指导临床治疗有重要意义。
PurposeTo explore the correlation between apparent diffusion coefficient （ADC） value on MR diffusion-weighted imaging （DWI） and prognostic factors in breast invasive ductal carcinomas.Materials and Methods 103 patients with pathology-proven invasive breast ductal carcinomas underwent DWI MR scan using b=1000 s/mm^2. The minimum ADC values of the lesions were determined. Histopathological specimens were analyzed for tumor size, lymph node metastasis, pathological grade （traditional prognostic factors） and the expression of prognostic factors including Ki-67, ToPo-IIα, P53 and CyclinD1. The correlations between ADC values and these prognostic factors were evaluated.Results In 103 breast invasive ductal carcinomas, there was no significant relationship between tumor size, lymph node metastasis, pathological grade and mean ADC values （P〉0.05）. The correlations between mean ADC values and the biological prognostic factors were not significant （P〉0.05）. However, positive correlations were observed between pathological grade and the expression of Ki-67 as well as ToPo-IIα（P〈0.05）.Conclusion ADC values cannot serve as a prognostic factor for invasive ductal breast carcinomas. However, the expression of Ki-67 and ToPo-IIα in breast invasive ductal carcinomas may be important in evaluating prognosis of the tumor and guiding clinical therapy.
出处
《中国医学影像学杂志》
CSCD
北大核心
2015年第3期183-187,共5页
Chinese Journal of Medical Imaging
关键词
癌
导管
乳腺
磁共振成像
弥散
扩散加权成像
表观扩散系数
预后
KI-67抗原
DNA拓扑异构酶类
II型
Carcinoma, ductal, breast： Diffusion magnetic resonance imaging
Diffusion weighted imaging
Apparent diffusion coefficient
Prognosis
Ki-67 antigen
DNAtopoisomerases, type II
