摘要
肠道病毒71型(EV71)是有高度嗜神经性的正链RNA病毒,属于小RNA病毒科肠道病毒属,近几十年来,EV71在中国大陆、中国台湾、马来西亚等亚太地区流行。EV71主要引起青少年手足口病和疱疹性咽峡炎,也可引起脑干脑炎等严重并发症,其中神经源性肺水肿(NPE)是最严重的并发症及主要死亡原因之一。EV71感染引起NPE的确切发病机制仍不清楚。该文从儿茶酚胺分泌异常、细胞因子异常、免疫紊乱、呼吸肌麻痹、年龄及基因等方面对EV71感染并发NPE的机制进行阐述。
Enterovirus 71（EV71）,a-highly-neurotropic,positive-sense single-stranded RNA virus,belongs to the Enterovirus genus of Picornaviridae family.In recent decades,EV71 spreads mainly in China's Mainland,Taiwan,Malaysia and other Asia-pacific regions.EV71 infections mainly cause hand,foot,and mouth disease and herpangina in young children,though it may also cause brain stem encephalitis,and circulation problems,among which neurogenic pulmonary edema（NPE） is one of the most serious complications and main causes of death.How EV71 infection causes NPE and its exact pathogenesis is still unclear.Here is make an elaboration focusing on the pathogenesis of EV71 infection combined with NPE from the aspects of abnormal secretion of catecholamine,cytokine abnormalities,immune disorder,respiratory myoparalysis,age,and gene etc.
出处
《医学综述》
2015年第7期1178-1180,共3页
Medical Recapitulate
基金
广西医疗卫生重点科研课题(重2012008)
关键词
神经源性肺水肿
肠道病毒71型
手足口病
Neurogenic pulmonary edema
Enterovirus 71
Hand-foot-mouth disease
