摘要
目的探讨心肌酶谱和脑脊液检查在诊断手足口病(HFMD)并发全身炎症反应综合征(SIRS)和多器官功能障碍综合征(MODS)中的价值。方法对2010年4月至2013年1月于该院就诊的204例HFMD患儿进行回顾性分析,对患儿进行心肌酶谱和脑脊液检查,分析检查结果与SIRS和MODS发生的相关性。结果重型和危重型组SIRS发病率、MODS发病率、病死率均高于普通型组,差异有统计学意义(P<0.05)。SIRS组脑脊液蛋白含量、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)和肌钙蛋白T(cTnT)含量高于非SIRS组,差异有统计学意义(P<0.05)。MODS组脑脊液蛋白含量、CK-MB、LDH和cTnT含量高于非MODS组,差异有统计学意义(P<0.05)。Spearman秩相关分析结果显示,脑脊液蛋白、CK-MB、cTnT与SIRS、MODS发病呈正相关(P<0.05)。结论脑脊液和心肌酶谱检查在早期诊断HFMD并发SIRS和MODS中具有较高的价值。
Objective To investigate the value of myocardial enzymes and cerebrospinal fluid examination in diagnosis of hand, foot and mouth disease（HFMD） complicated with systemic inflammatory response syndrome（SIRS） and multi-organ dysfunction syndrome（MODS）. Methods During April 2010 to January 2013,204 cases were retrospectively analyzed and checked myocardial enzymes and cerebrospinal fluid examination of the children to analyze the correlation between inspection results and incidence of SIRS and MODS. Results The incidence of SIRS and MODS and mortality rate of severe and critical group was significantly higher than ordinary group（P〈0.05）. CSF protein, CK-MB, LDH and cTnT content of SIRS group were significantly higher than non- SIRS group（P〈0.05）. CSF protein,CK-MB,LDH and cTnT content of MODS group were significantly higher than non-MODS group（P〈0.05）. Spearman rank correlation analysis showed that CSF protein,CK-MB and cTnT was positively correlated to inci- dence of SIRS and MODS（P〈0.05 ,P〈0.05）. Conclusion Myocardial enzymes and cerebrospinal fluid examination have a higher value in diagnosis of HFMD complicated with SIRS and MODS.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第31期3721-3723,共3页
Chongqing medicine
基金
国家自然科学基金资助项目(81071591)
关键词
手足口病
全身炎症反应综合征
多器官功能衰竭
心肌酶谱
脑脊液
hand, foot and mouth disease
systemic inflammatory response syndrome
multiple organ failure
myocardial en-zymes
cerelorospina[ fluid
