摘要
目的研究护心康防治动脉粥样硬化的作用机制。方法采用高脂喂饲复制兔动脉粥样硬化模型,将护心康分为低、中、高剂量3个剂量组进行干预治疗,检测给药后动脉管壁NF-κB的变化。结果护心康中、高剂量组NF-κB均较模型组低(P<0.05);低剂量组和模型组之间差异无统计学意义(P>0.05);高剂量组和中剂量组之间差异无统计学意义(P>0.05)。结论护心康具有降低动脉管壁NF-κB的作用。
Objective To explore the mechanism of Huxinkang in prevention and treatment of atherosclerosis. Methods Ninety male Chinese white rabbits were randomly divided into 5 groups： the normal control group,the model group,Huxinkang low-,middle- and high- dose groups. The rabbits of each group were fed with high cholesterol diet for 63 days except rabbits of the normal control group. The samples of aorta were taken for detecting the changes of nuclear transcription factor- κB（ NF- κB）in the AS plaque. Results The expression of NF- κB in AS plaque was decreased in the middle- and high- dose groups compared with the model group（ P 〈0. 05）. And no statistically significant difference was found between the low- dose group and the model group as well as between the middle- and high- dose groups（ P 〉0. 05,P 〉0. 05）. Conclusions Huxinkang can decrease NF- κB in artery plaque.
出处
《实用预防医学》
CAS
2015年第5期613-614,共2页
Practical Preventive Medicine
基金
湖南省教育厅科学研究项目(09B074)
湖南省中药粉体与创新药物研究省部共建国家重点实验室培育基地开放基金项目(ZYFT201304)
