摘要
目的:研究护心康对兔动脉粥样硬化防治的作用机制。方法:采用高脂喂饲复制兔动脉粥样硬化模型,将护心康分为低、中、高3个不同剂量组进行干预治疗,原位杂交法检测动脉管壁TLR4mRNA的变化。结果:护心康中、高剂量均有较好的降低兔动脉管壁TLR4mRNA的作用,高剂量作用优于低剂量,差异有统计学意义(P<0.05)。结论:护心康具有降低动脉管壁TLR4mRNA的功效。
Objective： To explore the mechanism of Huxinkang on atherosclerosis rabbit . Methods：Atherosclerosis rabbits were induced by high lipid diet. The rabbits were divided into Huxinkang low, middle and high dose groups. The samples of aorta were taken for TLR4mRNA in the AS plaque. Results： The expression of TLR4mRNA in AS plaque were all increased obviously in the Huxinkang low, middle and high dose groups. The high dose group is better than low dose group （P〈0.05） . Conclusion： Huxinkang can decrease TLR4mRNA in plaque.
出处
《中医药导报》
2013年第2期88-89,共2页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
湖南省中医药科研计划项目(2009023)
湖南省教育厅科学研究项目(09B07)
湖南省自然科学基金项目(10JJ3054)
