摘要
目的探讨冠心病(CHD)患者外周血核因子κB(NF-κB)的变化及其临床意义。方法入选163例患者,CHD组103例,其中ACS组71例,SAP组32例,对照组60例。检测外周血浆NF-κB浓度。同时经选择性冠状动脉造影检查。比较不同冠状动脉病变支数、冠状动脉病变程度、冠状动脉病变类型的血浆NF-κB水平;并进行冠心病患者Gensini积分与NF-κB等危险因素的多因素logistic回归分析。结果①ACS组、SAP组与对照组相比NF-κB浓度明显升高,且ACS组较SAP组升高更明显,差异有统计学意义(P<0.01);②单支、双支、三支病变组、对照组各组间NF-κB浓度比较差异有统计学意义(P<0.01),但单支病变组与对照组比较差异无统计学意义;③轻度、中度、重度病变组、对照组各组间NF-κB浓度比较差异有统计学意义(P<0.01),但轻度病变组与对照组比较差异无统计学意义;④A型、B型、C型病变组、对照组各组间NF-κB浓度比较差异有统计学意义(P<0.01),但A型病变组与对照组比较差异无统计学意义;⑤Gensini积分与CHD危险因子logistic回归分析显示高水平核因子κB、高血压、高脂血症、年龄>60岁、男性均为严重冠状动脉病变的相关危险因素。结论 CHD患者NF-κB活性增高,是严重冠脉病变的相关危险因素,在CHD发生、发展中可能起着重要作用。
Objective To investigate the changes and clinical significance of peripheral plasma nuclear factor- κB （NF-κB） in the patients with coronary heart disease （CHD）. Methods There were totally 163 patients selected, and 103 in CHD group including 71 in acute coronary syndrome group （ACS group） and 32 in stable angina pectoris group （SAP group）, and 60 in control group. The concentration of NF-κB in peripheral plasma was detected, and at the same time, coronary angiography （CAG） was used selectively for defining the pathological changes of coronary artery. The level of plasma NF-κB was observed among different vessels, status and types of CHD, and Gensini integrals and CHD risk factors including NF-κB were given Logistic regression analysis. Results （1）The concentration of NF-κB in- creased significantly in ACS group and SAP group compared with control group, which was more significant in ACS group than that in SAP group （P 〈 0.01 ）. （2）The comparison in the concentration of NF-κB was statistically different among single vessel group, two vessel group, three vessel group and control group （P 〈 0.01 ）, but that was not statisti- cally different between single vessel group and control group.（3）The comparison in the concentration of NF-κB was sta- tistically different among mild group, medium group, severe group and control group （P 〈 0.01 ）, but that was not statis- tically different between mild group and control group. （4）The comparison in the concentration of NF-κB was statistical- ly different among type A group,type B group ,type C group ,type D group and control group （P 〈0.01 ）, but that was not statistically different between type A group and control group. （5）The Logistic regression analysis of Gensini inte- grals and CHD risk factors showed that high level of NF-κB, hypertension, high blood fat, age over 60 and male were all risk factors of severe CHD. Conclusion The increase of NF-κB activity is a relative risk factor of severe coronary dis- ease in CHD patients, which plays an important role in the occurrence and development of CHD.
出处
《中国循证心血管医学杂志》
2012年第3期204-207,共4页
Chinese Journal of Evidence-Based Cardiovascular Medicine
