摘要
目的:探讨2007-2011年大连地区大肠癌临床流行病学特征,为大肠癌的早期防治提供流行病学依据.方法:采用回顾性调查方法,分析大连市中心医院住院的993例初次就诊大肠癌患者的临床流行病资料,分析其临床及病理特点、相关诊治及预后.结果:993例大肠癌患者发病平均年龄66.7岁,男女比例为1.19∶1.直肠是大肠癌常见部位(42.8%),女性右半结肠癌患病率显著高于男性(P<0.05).溃疡型中分化腺癌是最常见的病理类型,患者初诊时Ducks分期B、C、D期共占95.3%.便血、腹痛、大便习惯改变是大肠癌最常见的临床症状(69.3%),其最常见的合并疾病是大肠息肉.O型血患者占34.3%、B型血占27.3%.治疗大肠癌的主要方法是外科手术(82.5%),最常见的转移部位肝脏(42.4%),复发最常发生在术后18mo内(76.9%).癌胚抗原(carcinoembryonic antigen,CEA)和糖链抗原199(carbohydrate antigen 199,CA199)联合检测率(>60%)优于单一指标的检测.结论:大连地区大肠癌患者中位发病年龄69岁,就诊时多为临床中晚期,便血、腹痛、大便习惯改变是大肠癌最常见的临床症状,最常见的合并疾病是大肠息肉,肝脏是最常见的转移部位,外科手术治疗仍是大肠癌的主要治疗手段,5年间有中低分化腺癌的发病率增加、低分化腺癌减少的趋势.
AIM： To investigate the clinical and epidemiological characteristics of colorectal cancer（CRC） in Dalian, China from 2007-2011, and provide epidemiological evidence for early prevention and treatment of CRC. METHODS： Clinical and epidemiological data for 993 newly treated CRC patients at Dalian Central Hospital from 2007 to 2011 were retrospectively reviewed. Clinical and pathological characteristics, treatment and prognosis of CRC were analyzed. RESULTS： The average age of the 993 patientswith CRC was 66.7 years, and the ratio of male to female is 1.19∶1. The prevalence of right colon cancer in females was higher than that in males（P〈0.05）. The ulcer-type moderately differentiated adenocarcinoma was the most common type, and Ducks B, C and D disease accounted for 95.3%. Bloody stools, abdominal pain, and change in bowel habits were the most common clinical symptom（69.3%）, and the most common complication was colorectal polyps. Patients with O-type blood accounted for 34.3%, and those with B-type blood accounted for 27.3%. Main treatment for CRC was surgical operation（82.5%）, and the most common site of metastasis was the liver（42.4%）. Postoperative recurrence was most commonly seen at 18 mo（76.9%）. Joint detection of carcinoembryonic antigen（CEA） and carbohydrate antigen 199（CA199）（60%） was better than detection of either marker in the diagnosis of the disease. CONCLUSION：Patients with newly diagnosed CRC usually have middle-late stage disease in Dalian, and the median age of onset is 69 years. Bloody stools, abdominal pain, and change in bowel habits are the most common clinical symptoms, and the most common complication is colorectal polyps. The main treatment for CRC is surgical operation, and the most common site of metastases is the liver. The constituent ratio of poorly-moderately differentiated adenocarcinoma increases, and the poorly differentiated adenocarcinoma has a decreasing trend.
出处
《世界华人消化杂志》
CAS
2015年第7期1191-1195,共5页
World Chinese Journal of Digestology
关键词
大肠癌
流行病学
临床特征
大连
Colorectal cancer
Epidemiology
Clinical features
Dalian
