摘要
背景与目的：神经内分泌肿瘤（neuroendocrine neoplasm，NEN）是一组罕见的、起源于神经内分泌细胞和肽能神经元的异质性肿瘤，近年来发病率呈不断上升的趋势。本研究旨在分析大连地区NEN的流行病学和临床病理学特征，为防治NEN提供依据。方法：采用回顾性调查方法，收集2000—2013年经大连医科大学附属第一医院病理科证实的NEN患者，研究其流行病学特征、病变部位和病理类型，并对性别、年龄等因素进行统计学分析。结果：共有NEN患者279例，总检出率2．58／万人，男性166例，女性113例，男女比例为1．47：1，患者的平均年龄（59．4±17．1）岁（20～83岁），男性平均年龄（58．9±19．4）岁（20～81岁），女性平均年龄（61．7±15．0）岁（29～83岁），不同性别的检出率及年龄差异无统计学意义。病变部位以消化系统最为常见（71．68％），肺和支气管次之（20．79％），纵隔、乳腺、子宫等其他部位较罕见，不同性别在病变部位上差异无统计学意义（P〉0．05）。NEN的3种病理类型中，神经内分泌瘤（neuroendocrine tumor，NET）132例（47．31％），神经内分泌癌（neuroendocrine cancer，NEC）140例（50．18％），混合性腺神经内分泌癌（mixedadenoneuroendocrine carcinoma，MANEC）7ff0（2．51％），不同性别的病理类型差异无统计学意义（P〉O．05），不同年龄段间的NET和NEC差异有统计学意义（P〈O．05），MANEC无统计学意义（P〉0．05）。结论：大连地区的NEN检出率近年呈上升趋势，应注意该病的早期筛查和防治。
Background and purpose： Neuroendocrine neoplasm is one kind of infrequent neoplasms from neuroendocrine cell and peptidergic neurons. This study aimed to investigate the epidemiology and clinicopathological characteristics of neuroendocrine neoplasms （NEN） in Dalian. Methods： We retrospectively analyzed all neuroendocrine neoplasms patients in First Affiliated Hospital of Dalian Medical University from 2000 to 2013. The epidemiology characteristics, pathogenic sites and pathological types were reviewed, and the differences between gender and age were also analyzed. The statistics analysis such as independent-samples t test and one-way ANOVA and chi-square test were performed. Results： There were 279 NEN cases, including 166 male and 113 female patients （male： female=1.14： 1）, detection rate was 0.258%. The mean age of all cases was 59.44±17.1 （20-83）, for male 58.9±19.4 （20-81） and female 61.74±15.0 （29-83）. There was no statistical significance of detection rate and mean age between male and female patients. Digestive system was the most common occurred site of NEN （71.68%）, then was the respiratory system （20.79%）. There was no statistical significance of pathogenic sites between male and female.In all case, 132 with neuroendocrine tumor （47.31%）, 140 with neuroendocrine cancer （50.18%）, 7 with mixed adenoneuroendocrine carcinoma （2.51%）. There was no statistical significance of pathological types between male and female （P〉0.05）.Conelusion： Recently, the detection rate of neuroendocrine neoplasms was raised in Dalian, but there was no significance differences in detection rate, pathogenic sites and pathological types between male and female.
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2014年第2期146-150,共5页
China Oncology
基金
辽宁省科学计划项目课题(No:2012225020)
关键词
神经内分泌肿瘤
流行病学
病理特点
Neuroendocrine neoplasms
Epidemiology
Clinicopathological characteristics
