摘要
目的通过检测主动脉夹层患者血浆中白细胞介素(IL)-6、肿瘤坏死因子-α(TNF-α)和C-反应蛋白(CRP)3种炎症介质的浓度,探讨其在病程中的变化及临床意义。方法分别使用ELISA法检测68例主动脉夹层患者、50例单纯原发性高血压患者及50例健康成人血浆中的IL-6、CRP、TNF-α浓度,将主动脉夹层组按照病程不同分为包含急性期到慢性期的9个时间段组别进行统计,分析夹层组炎症介质与另两组的差异及其随时间的变化趋势。结果主动脉夹层患者血浆中IL-6、CRP、TNF-α浓度均比正常人组、单纯原发性高血压组高(P<0.05),3种炎症因子浓度峰值均出现于主动脉夹层病程急性期内,在亚急性期、慢性期逐渐降低。结论主动脉夹层患者血浆中IL-6、CRP和TNF-α在病程中扮演重要角色,炎症因子可作为评估主动脉夹层患者全身炎症反应的强度、辅助诊断及评估早期预后的指标。
Objective To investigate the clinical significances of plasma IL-6,CRP and TNF-αconcentration changes in aortic dissection.Methods Plasma concentrations of IL-6,TNF-αand CRP were determined in 68 aortic dissection patients,50 patients with essential hypertensionand 50 healthy volunteers.The changes of plasma IL-6,CRP and TNF-αconcentration were analyzed in aortic group along with the progression of the disease which was divided into 9different time courses.Results Compared with essential hypertension and healthy control group,significantly elevated CRP,IL-6and TNF-αconcentrations were detected in aortic dissection patients（P0.05,respectively）.All the concentrations of CRP,IL-6and TNF-αreached the peak in acute phase of aortic dissection and then gradually declined in subacute and chronic phase.Conclusion Increased plasma inflammatory factors were significantly associated with aortic dissection.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2015年第2期234-237,共4页
Journal of Sichuan University(Medical Sciences)
关键词
主动脉夹层
炎症因子
全身炎症反应
变化趋势
Aortic dissection
Inflammatory factor
Systemic inflammatory response
Trends
