摘要
放射免疫方法检测10例原发性高血压和19例各种肾脏病所致尿毒症患者血浆内皮素(ET)浓度,与87例正常人值相比。正常对照组血浆ET浓度为45.5:k17.6Pg/ml;不同年龄正常人血浆ET值无差别。与对照组相比,原发性高血压与尿毒症患者血浆ET值分别呈中度和明显升高(P均<0.01)。结果表明正常儿童至成人血浆ET水平较为恒定;提示血浆ET值与原发性高血压发病有一定关系,尿毒症患者血浆ET值升高可加重肾功能损害。
Concentrations of plasma endothelin(ET) were measured by radioimmuno-assay in 10 cases of primary hypertension and 19 oases of uremia resulting from various kidney diseases and compared with those in 87 normal humans, The concentrations of plasma ET in the normal controls were 45.5±17.6pg/ml. No significant difference in ET concentrations could be found among various age groups. Compared with the controls, the values of ET in patients with primary hypertension and uremia were slightly and markedly increased respectively (P<0.01). These results suggest that the plasma ET level is constant in normal children and adults. The pathegenesis of primary hypertension may be related to ET. High plasma ET levels may result in further damage to renal function in patients with uremia.
出处
《上海医科大学学报》
CSCD
1990年第5期386-388,共3页
Journal of Fudan University(Medical Science)
关键词
高血压
尿毒症
血浆内皮素
plasma endothelin
primary hypertension
uremia
