摘要
目的探讨血浆中IL-6、Aβ1-40、M-CSF、IL-1β、TNF-α对阿尔茨海默病(AD)的临床诊断意义。方法选择AD患者组74例,另选取100名健康老年者作为对照组。应用ELISA方法检测血浆Aβ1-40、IL-6、M-CSF、IL-1β、TNF-α水平。结果 (1)AD患者血浆Aβ1-40浓度[(108.4±6.5)pg/mL]与对照组[(103.5±7.1)pg/mL]比较,差异无统计学意义(P>0.05)。IL-6、M-CSF、IL-1β、TNF-α浓度分别为(180.9±50.6)pg/mL、(524.6±68.1)pg/mL、(40.45±6.14)pg/mL、(60.52±5.64)pg/mL,与正常对照组[(75.2±45.1)pg/mL、(320.5±80.8)pg/mL、(30.46±7.50)pg/mL、(36.64±15.32)pg/mL]比较,差异均有统计学意义(P<0.01)。结论检测AD患者血浆中Aβ1-40浓度对诊断无意义,而IL-6、M-CSF、IL-1β、TNF-α水平的检测可以成为临床辅助诊断AD的生物学指标。
Objective To explore the clinical diagnositic significance of the interleukin-6 （IL-6）, amyloid protein Aβ1-40 （Aβ1-40）, macrophage clony stimulating factor （M-CSF）, interleukin-1β（IL-1β） and tumor necrosis factor-α（TNF-α） in plasma in Alzheimer＇s disease （AD）. Methods Seventy four AD patients were chosen, and 100 healthy elderly were selected as the control. ELISA test methods were used to test the level of IL-6, Aβ1-40, M-CSF , IL-1β and TNF-αin peripheral blood. Results Plasma Aβ 1-40 concentration in AD patients of （108.4±6.5） pg/mL had no significant difference compared with the control group of （103.5±7.1） pg/mL （P 0.05）. The concentration of IL-6, Aβ1-40, M-CSF , IL-1β,TNF-α in AD patients all had statistical significance compared the controls （P 0.01）, with the comparison of （180.9±50.6） pg/mL vs （75.2±45.1） pg/mL, （524.6±68.1 ） pg/mL vs （320.5±80.8） pg/mL, （40.45±6.14） pg/mL vs （30.64±7.50） pg/mL,（60.52±5.64） pg/mL vs （36.64±15.32） pg/mL. Conclusion The test of Aβ1-40 level in plasma may be meaningless for the diagnosis of AD, the test of IL-6, M-CSF, IL-1β, TNF-α level may be meaningful for clinical diagnosis as a biological indicator for AD.
出处
《中国当代医药》
2012年第34期17-18,23,共3页
China Modern Medicine
关键词
阿尔茨海默病
IL-6
AΒ1-40
M-CSF
IL-1Β
TNF-α
Alzheimer＇s disease
Interleukin-6
Amyloid protein Aβ1-40
Macrophage clony stimulating factor
Interleukin-1β
Tumor necrosis factor-α
