摘要
目的研究抑制素A在早期正常妊娠、稽留流产患者绒毛中的定位及表达水平，探讨抑制素A-9稽留流产的相关性。方法选取2012年8月至2013年10月期间自愿在我院妇科终止妊娠的80例患者，其中20例正常早孕要求人工流产者为对照组，稽留流产60例，后者根据胚胎停止发育至排出母体外的时间，分成A组（〈2周），B组（2—4周）以及C组（〉4周）（n=20）。采用免疫组织化学技术和计算机图像分析系统，检测绒毛组织中抑制素A表达情况。结果抑制素A在对照组、稽留流产组绒毛的合体滋养细胞、细胞滋养细胞、毛细血管内皮细胞的胞浆呈不同程度的阳性染色。稽留流产组绒毛抑制素A的表达水平明显低于对照组（P〈0．05），但A、B、c3组间表达无统计学意义（P〉0．05）。结论绒毛组织中抑制素A对于正常早期妊娠的维持起重要作用，抑制素A表达水平降低可能在稽留流产发生过程中具有重要作用。
Objective To study the expression of inhibin A in the villi of patients with normal early pregnancy and missed abortion, and the correlation between inhibin A and missed abortion. Methods 80 pa- tients registered to the Department of Gynecology in our hospital between August 2012 and October 2013 were collected. 20 cases of normal early pregnancy with artificial abortion were served as control group. 60 cases of missed abortion were divided into three groups according to the time between embryo death and removal from pregnant women ： Group A （~〈2weeks） , Group B （ 2 - 4weeks） and Group C （ I〉 4weeks） （ n = 20 ）. The ex- pression of inhibin A was determined by immunohistochemistry technology and computer image analysis sys- tems. Results Inhibin A exhibited positive staining at the cytoplasm of syncytiotrophoblast, cytotrophoblast and capillary endothelial cell of villi. The expression of inhibin A in the villi of the missed abortion group was less than that in the control group （ P 〈 0.05 ）. There were no significant differences of inhibin A expression in villi among groupA, B and C （ P 〉 0.05 ）. Conclusion Inhibin A from villi plays an important role in sustaining normal early pregnancy. The low expression of inhibin A may play an important role in the process of missed abortion.
出处
《湖北科技学院学报（医学版）》
2015年第1期16-18,共3页
Journal of Hubei University of Science and Technology(Medical Sciences)
基金
深圳市龙岗区科技创新局资助项目(YS2011073)
