摘要
用苯胺和环氧丙烷为原料,在铜系(Cu-Zn O-Mn O/Si O2)催化剂作用下闭环得到3-甲基吲哚。采用正交设计研究确定了最佳合成工艺参数为:n苯胺:n环氧丙烷为3:1,n H2O:n环氧丙烷为10:1,最终环合温度350℃,反应时间为25h。在最佳条件下收率达66%以上,纯度为98%以上,达到了优化的目的。
In this article, we used Aniline and Epoxy propane as raw materials, under the copper System （Cu-ZnO-MnO / SiO2） catalyst, closed-loop and successfully obtain 3-methyl-indole. By studying the orthogonal design,we determine the optimum synthesis process parameters： n Aniline ： n Epoxy propane is 3：1, nH2O： n Epoxy propane is 10：1, The final cyclization temperature 350 ℃, reaction time is 25h. Under the optimal conditions, the yield was above 66%, the purity was more than 98%. In this way, we achieve the purpose of optimization.
出处
《武汉纺织大学学报》
2014年第6期64-67,共4页
Journal of Wuhan Textile University
关键词
3-甲基吲哚
合成
工艺优化
3-methyl Indole
Synthesis
Process Optimization
