摘要
目的探讨妊娠期糖尿病(GDM)患者血清中的C反应蛋白(CRP)及25-羟维生素D3的水平变化与妊娠期糖尿病发病的关系。方法选取2014年1—2月常熟市中医院门诊确诊的GDM患者50例为研究组,同期健康妊娠妇女50例为对照组,分别检测两组受试者血清CRP、25-羟维生素D3、空腹血糖(FPG)和空腹胰岛素(FINS)的水平,计算胰岛素抵抗指数(HOMA IR),对两组进行比较分析。结果研究组血清CRP水平高于对照组(P<0.01),而25-羟维生素D3水平低于对照组(P<0.01),CRP与HOMA IR呈正相关(P<0.01),而25-羟维生素D3与HOMA IR呈负相关(P<0.01)。结论CRP、25-羟维生素D3的水平与糖尿病患者有密切关系,可以通过检测CRP、25-羟维生素D3浓度监测妊娠期糖尿病病情的发生发展变化。
Objective To investigate the variations of serum C-reactive protein （CRP） and 25-hydroxy vitamin D3 in gestational di- abetes mellitus （GDM） and their clinical significance. Methods A total of 50 GDM patients and 50 healthy pregnant women were involved in the study. All the subjects were diagnosed between January and March 2014 in Changshu Hospital for Traditional Chi- nese Medicine. Serum CRP, 25-hydroxy vitamin D3, fasting plasma glucose （FPG） and fasting insulin （FINS） were assayed, and homeostasis model assessment of insulin resistance （HOMA-IR） was analyzed. Results On one hand, serum CRP was higher in the GDM patients than in the controls （P 〈0.01 ）. On the other hand, serum 25-hydroxy vitamin D3 was lower in the GDM patients than in the controls （P 〈 0.01 ）. HOMA-IR was positively correlated with CRP （P 〈 0.01 ） and negatively correlated with 25-hy- droxy vitamin D3 （ P 〈 0.01 ）. Conclusion Serum CRP and 25-hydroxy vitamin D3 play important roles in GDM. They can be em- ployed to monitor the progression of GDM.
出处
《临床军医杂志》
CAS
2015年第1期59-61,共3页
Clinical Journal of Medical Officers
