摘要
转录因子-缺氧诱导因子-1( HIF-1)在细胞适应从常氧(21%O2)到低氧(1%O2)的过程中扮演了重要角色。研究表明,HIF-1与人类多种恶性肿瘤的发生发展有着密切关系。本文就HIF-1在肿瘤的增殖、转移、凋亡和血管生成中的作用进行综述。
Transcription factorhypoxia inducible factor -1(HIF-1)plays a key role in cell adaption to hypoxia(from 21%O2 to 1%O2).Researches have shown that HIF -1 is closely related to occurrence and de-velopment in many malignant cancers .In this paper,we review the effect of HIF -1 in tumor growth,metastasis, apoptosis and angiogenesis .
出处
《实用肿瘤学杂志》
CAS
2014年第6期565-568,共4页
Practical Oncology Journal