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HIF-1与肿瘤相关性研究进展 被引量:2

Research progress of HIF - 1 in cancers
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摘要 转录因子-缺氧诱导因子-1( HIF-1)在细胞适应从常氧(21%O2)到低氧(1%O2)的过程中扮演了重要角色。研究表明,HIF-1与人类多种恶性肿瘤的发生发展有着密切关系。本文就HIF-1在肿瘤的增殖、转移、凋亡和血管生成中的作用进行综述。 Transcription factorhypoxia inducible factor -1(HIF-1)plays a key role in cell adaption to hypoxia(from 21%O2 to 1%O2).Researches have shown that HIF -1 is closely related to occurrence and de-velopment in many malignant cancers .In this paper,we review the effect of HIF -1 in tumor growth,metastasis, apoptosis and angiogenesis .
作者 张博 赵刚
出处 《实用肿瘤学杂志》 CAS 2014年第6期565-568,共4页 Practical Oncology Journal
关键词 缺氧 缺氧诱导因子-1 肿瘤 Hypoxia HIF - 1 Neoplasms
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参考文献26

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同被引文献15

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