摘要
目的探讨B型利钠肽(BNP)水平在预测慢性心力衰竭(CHF)患者预后中的价值。方法对98例CHF患者进行随访[(17.62±3.71)月],记录发生的心血管事件,分为心血管事件组与非事件组,分析不同BNP水平在预测CHF患者预后中的价值。结果事件组的年龄、收缩压和左心室舒张末内经(LVEDD)明显高于非事件组(P<0.05),BNP水平[(1156.85±838.16)ng/L]显著高于非事件组[(716.45±182.07)ng/L](P<0.01),左室射血分数(LVEF)[(40.85±6.72)%]显著低于非事件组的[(46.42±5.64)%](P<0.01)。以98例CHF患者BNP水平的中位数758 ng/L为分组界值,通过Kaplan-Meier法作不同BNP水平患者在随访期间心血管事件发生率曲线,可见BNP<758 ng/L组的随访曲线明显高于BNP>758 ng/L组,计算Log-rank值为15.22(P=0.000);以BNP中位数对CHF患者进行危险分层,中位数以上患者发生心血管事件的风险是中位数以下患者的3.1倍(P<0.01)。结论发生心血管事件患者的BNP水平显著增高,BNP水平在预测CHF患者的预后中有重要价值。
Objective To observe the prediction prognosis value of B-type natriuretic peptide （BNP）on prognosis for patients with congestive heart failure （CHF）.Methods Ninety-eight patients with CHF in our depart-ment were followed up for mean 1 7.6 months.Patints with CHF were divided into cardiovascular events group and non-cardiovascular events group,and the prognostic value of BNP on outcome for patients with CHF were analysed. Results Compared with non-cardiovascular events group,age,systolic blood presssure,and LVEDD were higher in the cardiovascular events group（P 〈0.05）,serum BNP level was increased（P 〈0.01 ）,left ventricular ejection frac-tions was decreased in the cardiovascular events group（P 〈0.01 ）.Kaplan Meier cumulative survival analysis showed that the survival rate of patients with BNP 〈758 ng/L（median）was much higher than that of patients with BNP 〉758 ng/L（P 〈0.01 ）.The event risk was 3.1 times higher in patients with BNP level above median compared with pa-tients with BNP level under median（P 〈0.01 ）.Conclusion Serum BNP level is significantly higher in patients with cardiovascular events,serum BNP has important prognosis value for patients with CHF.
出处
《中国临床保健杂志》
CAS
2014年第6期579-581,I0007,共4页
Chinese Journal of Clinical Healthcare
关键词
心力衰竭
利钠肽
脑
随访研究
Heart failure
Natriuretic Peptide,Brain
Follow-Up Studies
