心血管病患者血浆N-端脑钠素前体浓度与心功能的关系被引量：14

Correlations Between Plasma Concentration of NT-Pro Brain Natriuretic Peptide and Cardiac Function in Patients With Cardiovascular Diseases

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摘要目的 :研究心血管病患者血浆N 端脑钠素前体 (NT ProBNP)浓度与心力衰竭严重程度的关系。方法 :电化学发光双抗体夹心免疫法测定 65例心血管病患者及 16名健康体检者血浆NT ProBNP浓度 ,超声心动图测定不同心功能组患者心脏结构和功能 ,分析血浆NT ProBNP浓度、超声指标与NYHA心功能分级的关系。结果 :方差分析显示心血管病患者血浆NT ProBNP浓度显著高于健康体检者 ,且随着心力衰竭程度的加重而显著增加 (P <0 0 0 1)。多因素偏相关分析表明血浆NT ProBNP浓度和左心室舒张末期容积与NYHA心功能分级之间具有良好的正相关 (r =0 769,P <0 0 0 1及r =0 3 76,P =0 0 2 0 )。血浆NT ProBNP浓度 >2 0 0 pg/ml诊断心力衰竭的敏感性 10 0 % ,特异性 97% ,阳性预测值 98% ,阴性预测值 10 0 %。结论 :心血管病患者血浆NT ProBNP浓度随着心力衰竭严重程度的增加而升高 ,是评价心功能的敏感指标。 Objective: To demonstrate the correlations of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentration with severity of heart failure, underling heart disease and New York Heart Association(NYHA)functional classi fications in patients with cardiovascular disease. Methods: Plasma NT-ProBNP concentrations of patients with cardiovascular disease (n=65) and of normal controls (n=16) were measured by nonextracted, enzyme-linked, sandwich immunoassay (Elecsys)after admission. Constructive and functional parameters of heart were measured by echocardiography in 65 patients on the same time. Results: The plasma NT-ProBNP concentrations of patients were significantly higher than those of the normal controls. They also increased with the increased severity of heart failure according to NYHA functional classification (p<0.001). The plasma NT-ProBNP concentrations and left ventricular end diastolic volume(LVEDV)also had significant positive correlations with NYHA functional classification (r=0.769, p<0.001 and r=0.376, p=0.020, respectively). In the diagnosis of heart failure, a level of NT-proBNP >200 pg/ml had a sensitivity of 100%, a specificity of 97%, a positive predictive value of 98% and a negative predictive value of 100%. Conclusion: The plasma levels of NT-ProBNP increase significantly with the increased severity of heart failure (NYHA functional classes). The plasma NT-ProBNP concentration is a sensitive biochemical parameter for evaluating heart function.

作者赵玉生田亚平高伟刘红鹰原新红陈瑞王士雯程芮刘光华(

机构地区中国人民解放军总医院老年心血管病研究所中国人民解放军总医院生化科

出处《中国循环杂志》 CSCD 北大核心 2004年第1期46-49,共4页 Chinese Circulation Journal

关键词心血管病血浆N-端脑钠素前体浓度心功能 Pro brain natriuretic peptide Heart failure, congestive

分类号 R54 [医药卫生—心血管疾病]

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