摘要
目的观察慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者血清锁链素水平及其与病期、缺氧、二氧化碳潴留及肺功能减退间的相关性。方法 COPD急性加重期住院患者60例(急性加重期组),稳定期患者40例(稳定期组),另选同期健康体检者40例做对照(对照组)。采用酶联免疫吸附试验(ELISA)法检测各组血清锁链素,并测定三组血气分析动脉氧分压(PaO2)、动脉二氧化碳分压(PaCO2)、肺功能第一秒用力呼气容积占用力肺活量比(FEV1%FVC)及第一秒用力呼气容积占预计值百分比(FEV%pred)。结果 1急性加重期组、稳定期组及对照组受试者血清锁链素水平组间两两比较示均P<0.05,差异有统计学意义;2急性加重期组和稳定期组COPD患者血清锁链素水平与PaO2、FEV1%FVC及FEV%pred均呈负相关(r1=-0.775,r2=-0.815,r3=-0.681,均P<0.05),血清锁链素水平与Pa CO2呈正相关(r=0.735,P<0.05)。结论 COPD患者血清锁链素水平升高,可能与COPD的疾病严重程度相关。
Objective To explore the clinical significance of desmosine in the pathogenesis of COPD by observing the serum levels of desmosine in different stages of COPD and analyzing the relationships with blood gas analysis and lung function. Methods The study selected 60 cases of AECOPD, 40 cases of stable COPD and 40 cases of healthy people. Enzyme-linked immunosorbent assays （ELISA） method was used to detect the serum desmosine levels of the three groups, while the PaO2, PaCO2, FEV1% FVC and FEV1% pred were detected for all subjects. Resuits The serum levels of desmosine in the AECOPD group were significantly higher than those in the stable COPD group and the control group （P 〈0. 05）. The serum levels of desmosine in the AECOPD group and the stable COPD group were positively correlated with PaCO2 （ r = O. 735, P 〈 0. 05 ）, but negatively correlated with PaO2, FEV1% FVC and FEV1%pred （r1 = -0.775, r2 = -0. 815, r3 = -0.681, all P〈0. 05）. Conclusion The serum level of desmosine increases in COPD patients, which may be associated with clinical manifestations of COPD.
出处
《临床肺科杂志》
2015年第1期22-24,共3页
Journal of Clinical Pulmonary Medicine
关键词
慢性阻塞性肺疾病
锁链素
血气分析
肺功能
chronic obstructive pulmonary disease
desmosine
blood gas analysis
lung function
