摘要
目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清锁链素、C反应蛋白(CRP)水平及其与肺功能的相关性。方法选取AECOPD患者68例(AECOPD组)及健康体检者30例(对照组)。检测两组血清锁链素、CRP水平,并测定一秒钟用力呼气量占用力肺活量比值(FEV1/FVC%)及第一秒用力呼气容积占预计值百分比(FEV1%)。结果AECOPD组血清锁链素及CRP水平显著高于对照组(P<0.05),FEV1/FVC%及FEV1%低于对照组(P<0.05);AECOPD组患者治疗后血清锁链素、CRP水平显著低于治疗前(P<0.01);AECOPD组患者血清锁链素、CRP水平与FEV1/FVC%及FEV1%值均呈负相关(P<0.01),血清锁链素水平与CRP水平呈正相关(P<0.01)。结论 AECOPD患者血清锁链素、CRP水平升高,均与肺功能指标呈负相关;血清锁链素水平与CRP水平呈正相关,两者可能参与COPD及其炎症的发生、发展过程,这对评估患者的炎症严重程度具有重要的临床价值。
Objective To explore the serum levels of desmosine and C-reactive protein（ CRP） and their correlation with lung function in patients with acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods Sixty-eight patients with AECOPD（ AECOPD group） and 30 healthy persons（ control group） were enrolled in this study. The levels of serum desmosine and CRP,forced expiratory volume in one second to forced vital capacity ratio（ FEV1/ FVC%） and forced expiratory volume in the first second to predicted value ratio（ FEV1%） were detected in both groups. Results The serum levels of desmosine and CRP in the AECOPD group were significantly higher than those in the control group（ P 〈 0. 05）. FEV1/ FVC% and FEV1% in the AECOPD group were lower than those in the control group（ P 〈 0. 05）. In the AECOPD group,the serum levels of desmosine and CRP after treatment were significantly lower than those before treatment（ P 〈 0. 01）,the serum levels of desmosine and CRP negatively correlated with FEV1/ FVC% or FEV1%（ P 〈0. 01）,and serum desmosine level positively correlated with CRP level（ P 〈 0. 01）. Conclusion Serum levels of desmosine and CRP increase in the patients with AECOPD,which negatively correlate with lung function. The serum level of desmosine positively correlates with CRP level,and they may participate in the occurrence and development of COPD and its inflammation,which has the important clinical value for evalating the severity of inflammatory response in patients.
出处
《广西医学》
CAS
2015年第11期1620-1623,共4页
Guangxi Medical Journal
关键词
慢性阻塞性肺疾病
急性加重期
锁链素
C反应蛋白
肺功能
Chronic obstructive pulmonary disease
Acute exacerbation
Desmosine
C-reactive protein
Lung function
