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MMP-2、TNF-α和IL-10对胎膜早破合并绒毛膜羊膜炎的诊断价值 被引量：9

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摘要 目的探讨基质金属蛋白酶-2(MMP-2)、肿瘤坏死因子-α(TNF-α)和白细胞介素-10(IL-10)对胎膜早破合并绒毛膜羊膜炎的诊断价值。方法选择胎膜早破患者118例,其中合并绒毛膜羊膜炎79例,无合并绒毛膜羊膜炎39例,分别收集患者的血清和羊水,采用酶联免疫吸附法检测血清和羊水中MMP-2、TNF-α和IL-10的含量,所有孕妇均于剖宫产术后留取胎膜组织进行病理学检查,分析血清和羊水中MMP-2、TNF-α和IL-10含量与绒毛膜羊膜炎严重程度的相关性,及对胎膜早破合并绒毛膜羊膜炎的诊断价值。结果胎膜早破合并绒毛膜羊膜炎患者血清MMP-2、TNF-α和羊水TNF-α含量明显高于无合并绒毛膜羊膜炎患者(P<0.05),羊水IL-10含量明显低于无合并绒毛膜羊膜炎患者(P<0.05),两者血清IL-10含量差异无统计学意义(P>0.05);血清MMP-2和羊水TNF-α的含量与绒毛膜羊膜炎严重程度呈正相关(P<0.001,P<0.05),羊水IL-10含量与绒毛膜羊膜炎严重程度呈负相关(P<0.05);以羊水TNF-α>800 ng/L为阳性标准,其诊断胎膜早破合并绒毛膜羊膜炎的的敏感度、特异度、阳性预测值及阴性预测值最高。结论羊水TNF-α含量对胎膜早破患者合并绒毛膜羊膜炎具有较高的诊断价值,还可根据其浓度的高低,对绒毛膜羊膜炎的严重程度进行初步判断,为孕妇宫内感染的早期诊断提供依据。
作者 邓梅先 袁慧
机构地区 湖北省武汉市第五人民医院妇产科 江汉大学医学院医学系
出处 《广东医学》 CAS CSCD 北大核心 2014年第17期2717-2720,共4页 Guangdong Medical Journal
关键词 胎膜早破 绒毛膜羊膜炎 基质金属蛋白酶-2 肿瘤坏死因子-α 白细胞介素-10
分类号 R734.2 [医药卫生—肿瘤]
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参考文献11

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二级参考文献38

共引文献31

同被引文献95

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引证文献9

二级引证文献49

广东医学
2014年 第17期

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