摘要
采用高效液相色谱研究了抗肿瘤药物甲啶铂的水合反应,以及甲啶铂在0.9%NaCl溶液中的稳定性。结果表明,甲啶铂的水合反应遵循一级反应动力学规律,20℃时反应速率常数为k=0.03086h-1,半衰期22.5 h,反应活化能E=80.6 kJ/mol;在0.9%NaCl溶液中,甲啶铂的水合反应被抑制,反应达到平衡后,甲啶铂的降解不超过4%。
HPLC analytical method was used to investigate the aquation of picoplatin, and the stability of picoplatin in 0.9% NaC1 solution. The results show that the aquation of picoplatin followed the law of the first-order reaction, the rate constant was 0.03086 h^-1, the half life period was 22.5 h, the activation energy was 80.6 kJ/mol. Picoplatin is stable in 0.9% NaC1 solution, the degradation did not exceed 4% when the reaction achieved balance.
出处
《贵金属》
CAS
CSCD
北大核心
2014年第3期10-13,共4页
Precious Metals
基金
云南省科技厅重点新产品开发计划“抗肿瘤化学I类新药甲啶铂注射液的临床前预研究”(2013BC010)
关键词
药物化学
抗肿瘤药物
甲啶铂
水合反应
一级反应
medicinal chemistry
platinum-based anti-tumor drug
picoplatin
aquation
the first-orderreaction
