摘要
为合成抗肿瘤药物甲啶铂,采用醋酸铵与K2PtCl4反应生成K[Pt(NH3)Cl3],再先后与碘化钾、2-甲基吡啶、硝酸银、氯化钾反应生成甲啶铂。采用元素分析、质谱、核磁共振氢谱和红外光谱对其结构进行了表征。结果显示合成的化合物与理论一致,产率约为40%,可为甲啶铂的合成提供一条新的工艺路线。
To synthesize a platinum-based anti-tumor drug picoplatin, the key intermediate K[Pt（NH3）C13], synthesized from ammonium acetate and K2PtCI4 was subsequently reacted with KI, 2-picoline, AgNO3 and KC1 to give the target compound. The structure and component were characterized by elemental analysis, ESI-MS, 1H-NMR and IR. The results showed that its structure was consistent with the title compound and the yield was about 40%. This provides a new process for the synthesis of picoplatin.
出处
《贵金属》
CAS
CSCD
北大核心
2013年第4期37-39,共3页
Precious Metals
基金
云南省科技计划资助项目(2010DH021)
关键词
有机化学
铂配合物
甲啶铂
合成
organic chemistry
platinum complex
picoplatin
synthesis
