摘要
肺脏是严重烧伤、脓毒症后最早发生功能不全且发生率最高的器官，目前由于缺乏针对性强的有效防治方法，严重烧伤以及脓毒症合并肺损伤患者的病死率达43％～72％。近年来，学者观察到多种肺部疾病中存在自噬活性的变化，越来越多的研究表明自噬与脓毒症急性肺损伤之间存在密切关系，本文通过阐述自噬与脓毒症急性肺损伤的关系，了解自噬在脓毒症急性肺损伤过程中的分子调控机制，进而为脓毒症急性肺损伤的临床治疗提供新思路。
Sepsis is one of the most common pathogenetic causes of acute lung injury （ALI）,and at present there is still a lack of effective targeted techniques and methods for its prevention and treatment.Autophagy is a homeostatic mechanism common to all eukaryotic cells,including adaption to environment,defense against invasion of pathogens,and maintenance of cellular homeostasis.Autophagy is also involved in a variety of lung-related diseases.In septic lung injury,autophagy not only serves to dissipate dysfunctional organelles,but also inhibits the release of inflammatory cytokines.This review aims at eliciting the role of autophagy in sepsis-induced ALI and further exploring the potential targets of autophagy in inhibiting inflammation,in an effort to provide a new perspective for clinical treatment of sepsis-induced ALI.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2014年第4期325-328,共4页
Chinese Journal of Burns
基金
国家自然科学基金（81201443）
关键词
自噬
脓毒症
肺损伤
治疗靶点
Autophagy
Sepsis
l,ung injury
Therapeutic targets
