摘要
本文自1985年10月～1987年6月采用鲎试剂基质偶氮显色法定量检测烧伤病人血浆内毒素。12例严重烧伤病人,死亡4例(平均总面积63%/Ⅲ。18.5%),存活组8例(平均总面积58%/Ⅲ°24.4%);死亡组血浆内毒素浓度波动在105～571Pg/ml,明显高于存活组(30～240Pg/ml),是正常值(6.44±1.96Pg/ml)16.3倍,差异作常显著(P<0.01)。内毒素血症与创面脓毒症,阳性血培养和全身播散性败血病有密切关系;与全身应用敏感的抗生素有关。
Since october 1985 to June 1987, in 12 severely burned patients with endotoxemia was observed by using a quantitative endotoxin assay of limulus amoebocyte lysate (LAL) test with a chromogenic substrate. Among the 12 patients, 4 died and 8 survived. The average age of dead group was 31.8 years (19-45 years), mean TBSA was 63% (58-80%) and mean Ⅲ°18.5%. The survival group average age of survival group was 27.5 years(18-39 years), mean TBSA was 58% (18-85%) and mean Ⅲ°24.4% (6-56%). The plasma endotoxin concentrations of burn patients in dead group were 105-571pg/ml, significantly higher than that of survival group (30-240pg/ml) and healthy human (6.44+1.96pg/ml). It was found that the increase of endotoxemia was closely related to burn wound sepsis,positive of blood culture, systemic dissminated septieaemia. Systemic use of sensitive antibiotics may increase the level of blood endotoxin in severe gram-negative bacillus infeclion. Polymixin-B is an exception.
