摘要
目的研究褥疮康对体表溃疡模型小鼠创面愈合的影响及抗炎作用。方法制备创伤感染体表溃疡模型小鼠,按创面面积随机分为模型对照组、龙珠软膏6 g/kg组、褥疮康0.5,2,6 g/kg组,共5组,每组10只;另取10只正常小鼠作为正常对照组。将各组药物均匀涂敷于创面,厚度1 mm;模型对照组涂敷乙基纤维素;正常对照组不做处理。隔日给药1次,共5次。于术后1,5,10 d测量创口面积;末次给药1 h后,测量小鼠的耳廓肿胀度。结果治疗10 d后,褥疮康0.5 g/kg组、2g/kg组,小鼠创面面积显著减小;褥疮康2 g/kg组小鼠耳廓肿胀度显著低于模型组,肿胀抑制率达43.86%。结论褥疮康具有明显的生肌抗炎作用。
Objective To research the effect of Ruchuang Kang on the healing of the body surface ulcer in mice and its anti-inflammatory effect.Methods The infectious traumatic ulcer model on the body surface of mice was prepared.The model mice were randomly divided into model control group,Longzhu Ointment group,Ruchuang Kang 0.5 g/kg,2 g/kg,and 6 g/kg groups,10 mice in each group.Another 10 normal mice were used as normal control.The drugs were applied onto the wound uniformly,with the thickness of 1 mm.The wound of mice in model control group were coated with ethyl cellulose.Mice in normal control group were untreated.The mice were treated once every two days;all the animals were treated 5 times totally.1 d,5 d and 10 d later,the wound area was measured.1 h after the last treatment,the auricle swelling degree of mice was measured.Results After 10 days of treatment,the wound area of mice in the groups of Ruchuang Kang 0.5 g/kg and 2 g/kg decreased significantly.In the group of Ruchuang Kang 2 g/kg,the auricle swelling degree of mice was lower significantly than that of mice in the model group.The swelling inhibition rate reached 43.86 ％.Conclusion Ruchuang Kang has significant anti-inflammatory and granulationpromoting effects.
出处
《食品与药品》
CAS
2013年第6期402-404,共3页
Food and Drug
基金
山东省滨州市科技发展计划项目(200712)
关键词
褥疮
体表溃疡
生肌
抗炎作用
bedsore
body surface ulcer
granulation-promoting
anti-inflammatory action
