摘要
目的 :研究乳腺癌组织中基质金属蛋白酶 2 (MMP 2 )的表达特点 ,探讨其与间质微血管密度及肿瘤转移的关系。方法 :应用免疫组化S P法 ,检测 49例乳腺癌、10例癌旁正常组织MMP 2的表达 ,并在CD34染色切片上检测间质微血管密度(MVD)。结果 :乳腺癌组织MMP 2的表达 (75 5 % )明显高于癌旁正常组织 (30 % ) ,二者之间差异有显著性 (P <0 0 1) ;MMP 2阳性组MVD均值 (5 4 93± 13 86 )高于MMP 2阴性组 (4 1 2 8± 11 6 9) ,MMP 2的表达与MVD呈正相关 (P <0 0 1)。此外 ,乳腺癌MMP 2的表达与组织学分级、淋巴结转移密切相关 (P <0 0 5 ) ,而与患者年龄、肿瘤大小、组织学分型、临床分期无关。结论 :MMP 2促进乳腺癌间质血管生成 ,促进肿瘤的侵袭和转移 。
Purpose To study the expression of matrix metalloproteinase 2 (MMP-2) and its correlation with interstitial microvascular density (MVD) and tumor metastasis in breast carcinoma. Methods The expression of MMP-2 and MVD were detected in 49 cases of breast carcinoma and 10 cases of corresponding non-tumor normal tissue by immunohistochemical technique. Results In comparison with corresponding non-tumor normal tissue(30%), the expression of MMP-2 in breast carcinoma(75.5%) was significantly higher (P<0.01).MVD was much higher in the group of MMP-2 positive expression than that in the group of MMP-2 negative expression, there was a positive correlation between MMP-2 and MVD (P<0.01). In addition, the expression of MMP-2 was correlated with histological grade and lymph node metastasis(P<0.05),but there was no relationship with age, tumor size, histological type and clinical stage. Conclusions MMP-2 may promote the angiogenesis and play an important role in tumor invasion and metastasis .MMP-2 may be a important indicator to determine biological behavior and prognosis of breast carcinoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
2002年第3期279-282,共4页
Chinese Journal of Clinical and Experimental Pathology
