摘要
本文应用SD大鼠胆汁返流性急性胰腺炎(AP)模型,腹腔内注射丹参液治疗,发现治疗组血MDA含量(1小时和12小时分别为6.55±1.09和7.59±1.10nmol/ml)明显低于AP组(1小时和12小时分别为10.75±1.45和13.10±1.85nmol/ml)(P<0.01),治疗组血SODa含量(1小时和12小时分别为202±24和207±47u/ml)明显高于AP组(1小时和12小时分别为107±41和64±23u/ml)(P<0.01),胰重下降,病理改变减轻,大鼠病死率和病死鼠平均存活时间明显改善。有力提示丹参可通过抑制AP大鼠体内氧自由基的产生和增加其清除,而起到良好的治疗作用。
The present study using the bile-induced rat acute pancreatitis (AP) model treated by intraperitoneal injection of Salvia Miltiorrhiza (SM), discovered that the serum levels of malondialdehycle (MDA) in the treated group (6.55±1.09 and 7.59±1.10 nmol/ml in 1 h. and 12 h. respectively) were significantly lower than that in the AP group (10.75±1.45 and 13.10±1.85 nmol/ml in 1 h. and 12 h. respectively), the serum SOD activity (SODa) levels in the treated group (202±24 and 207±47 U/ml in 1 h. and 12h. respectively) were significantly higher than that in the AP group (107±41 and 64±23 U/ml in 1 h. and 12 h. respectively), the pancreas weight gain decreased, the pathologic changes mitigated, and the mortality and the mean survival time of the treated rats improved. These results strongly suggest that SM restrains the generation of oxygen derived free radicals (ODFR) and increases the elimination of ODFR in the bodies of AP rats, and that SM takes a satisfactory therapeutic effects.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第5期499-502,共4页
Chinese Journal of Pathophysiology
关键词
胰腺炎
丹参
抗氧化剂
Antioxidants
Acute pancreatitis
Rats
