摘要
本研究用兔78只,分两部分进行实验。第一部分,观察黄连注射液对家兔白细胞致热原(1eucocytic pyrogen;LP)性发热的降热效应;39只兔分成四组;Ⅰ为LP组;Ⅱ为黄连+LP组;Ⅲ为黄连组,Ⅳ为对照组。Ⅰ组9只兔,Ⅱ～Ⅳ组各10只兔。第二部分,观察黄连注射液对发热家兔脑脊液中cAMP含量变化的影响。动物数与分组同第一部分。结果表明,LP+黄连组60分钟△T℃(0.70±0.12),TRI_4(3.37±0.07)明显低于LP组△T℃(1.11+0.11)、TRI_4(5.56±0.10),分别比较两组△T℃、TRI_4,其差异性均非常显著(P<0.01)。上述两组动物60分钟脑脊液中cAMP含量分别为0.76±0.08和1.29±0.13,统计学处理后差异性非常显著(P<0.01)。黄连组动物60分钟△T℃(0.04±0.10)与对照组△T℃(0.03±0.06)相比较,无统计学意义(P>0.05)。作者推论:黄连注射液降热作用的机制,很可能与抑制POAH区神经元cAMP的生成有关。
78 rabbits in this study were divided into two parts and each part had 39 rabbits. In part Ⅰ and Ⅱ the effects of rhubarb injection on the febrile response and the change of cAMP contents in CSF in these rabbits were observed respectively. The results showed that LP+rhubarb group: △T (0.70±0.12); TPI_4 (3.37±0.07) and LP group:△T (1.11±0.11);TRI_4 (5.56±0.10) comparing of two groups, had markable statistical significance (P<0.01). In above two group cAMP content of CSF (60 min) was 0.76±0.08 and 1.29±0.13, respectively. Comparison of two groups had also a great statistical significance (P<0.01). We inferred that the mechanism of febrifugal effect of rhubarb injection might be associated with a drop of cAMP syntheses in brain.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第3期264-266,共3页
Chinese Journal of Pathophysiology
关键词
发热
致热原
腺苷环-磷酸
黄连
Adenosine cyclic monophosphate
Fever
Pyrogens
