摘要
在腹腔注射马桑内酯所致的大鼠慢性点燃癫痫模型上 ,应用小胶质细胞的特异性标记物蓖麻凝集素 - 12 0(Ricinus comm unis agglutinin- 12 0 ,RCA- 1)对大鼠海马和大脑皮质小胶质细胞及其形态学进行凝集素组化研究。结果显示 ,慢性癫痫大鼠小胶质细胞无序排列、散乱分布。小胶质细胞增生显著 ,RCA- 1受体表达增加 (P<0 .0 1) ,细胞体积增大 ,多数呈高度分枝状、多边形或圆形。表明在慢性癫痫大鼠的中枢神经系统中有小胶质细胞的持续激活 ,胶质增生 ,功能活跃 。
The chronic epileptic model was induced in rats by intraperitoneal injection of Coriaria lectone. Lectin histochemistry for the detection of microglial cells and their morphological changes were studied. Ricinus communis agglutinin 120 (RCA 1) was used as histochemical marker on sections of hippocampus and cerebral cortex. The results were as follows: The RCA 1 positive cells in model rats showed randomly arrangement, proliferation and hypertrophy; The expression of RCA 1 receptors was increased ( P <0.01) and more highly ramified or amoeboid microglia were found. Our study suggested that the continual activation and proliferation of microgliall cells in CNS might be related to the relapse of seizures.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2002年第4期356-358,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金
国家自然科学基金资助项目 (No.39970 379)
