摘要
目的 :研究可博利 2号口服液 (OKL- 2 )抗肝纤维化的作用。方法 :四氯化碳 (CCl4 )连续 8周皮下注射复制大鼠慢性肝纤维化模型。造模开始时即同时给予 OKL- 2 ,实验结束后分别测定肝功能、肝纤维化指标 (肝羟脯氨酸含量 ) ,并作肝组织病理学检查以观察肝纤维化的程度。结果 :OKL- 2可显著减轻 CCl4 所致肝纤维化程度 ,能明显降低肝羟脯氨酸含量 ,改善肝功能 ,肝组织病理学检查亦显示具有抗肝纤维化作用。结论 :OKL - 2对 CCl4
Objective:To investigate the effect of Keboli 2 Liquor (OKL 2) on experimental liver fibrosis.Methods:Liver fibrosis in rats was induced by carbon tetrachloride injected subcutaneously for 8 weeks.OKL 2 was given simultaneously.The liver function,liver hydroxyproline and histopathology were determined after that.Results:The liver fibrosis was ameliorated,the liver hydroxyproline was reduced and the liver function was improved significantly.Histopathology showed the effect of anti liver fibrosis of OKL 2.Conclusion:The protection of OKL 2 against liver fibrosis in rats induced by carbon tetrachloride was significant.
出处
《山西中医》
2002年第4期51-53,共3页
Shanxi Journal of Traditional Chinese Medicine
