摘要
目的 检测分析己酮可可碱抗小鼠血吸虫病肝纤维化前后血清TNF -α ,IFN -γ水平的变化。方法 建立血吸虫病肝纤维化小鼠模型 ,应用ELISA方法检测血吸虫病肝纤维化小鼠在己酮可可碱治疗前后血清TNF -α ,IFN -γ水平的变化。结果 己酮可可碱治疗可降低血清TNF -α的含量 ,高剂量治疗组与感染组相比P <0 0 1,而低剂量组与感染组相比P<0 0 5 ,高剂量组与低剂量组间有极显著性差异 (P <0 0 1) ;己酮可可碱治疗后可提高IFN -γ的含量 ,高剂量己酮可可碱治疗组和低剂量治疗组与感染组相比P值均小于 0 0 1,高剂量组与低剂量组间有显著性差异 (P <0 0 5 ) ;高剂量治疗组疗效与吡喹酮治疗组相比无统计学上的差异 (P >0 0 5 )。结论 己酮可可碱可明显降低血吸虫病肝纤维化小鼠血清TNF -α ,提高IFN -γ的水平从而发挥其抗肝纤维化的作用 。
Aim To study the effects of pentoxifylline on the serum level of TNF α and IFN γ in schistosomiasis mice with liver fibrosis Methods Using ELISA technique to observe the changes of serum level of TNF α and IFN γ in schistosomiasis mice with liver fibrosis before and after pentoxifylline treatment Results Pentoxifylline treatment could reduce the serum level of TNF α and increase that of IFN γ level in schistosomiasis mice with liver fibrosis significantly,with statistical significance between high dose group and low dose group(P<0 05) Conclusion Pentoxifylline treatment could reduce the serum level of TNF α and increase the serum level of IFN γ significantly in schistosomiasis mice with liver fibrosis in a dose dependent manner,thereby,play its role against hepatic fibrosis
出处
《中国人兽共患病杂志》
CAS
CSCD
北大核心
2002年第4期78-79,共2页
Chinese Journal of Zoonoses
基金
湖北省卫生厅科学研究资金资助
