摘要
目的 :观察骨质疏松症骨骼中元素含量变化及其相互的关系。方法 :10月龄雌性 SD大鼠切除双侧卵巢(去卵巢模型组 ) ,并设假手术组 ,7个月后取胫骨 ,原子吸收分光光度法测定 Ca、P、Mg、Zn、Mn、Fe、Cu、Co、Mo和Cr含量 ,并对各元素的含量之间进行一元回归分析。结果 :骨质疏松症模型大鼠胫骨除 Ca、P和 Mg等常量元素分别下降 6 .6 % (P<0 .0 5 )、6 .3% (P<0 .0 5 )和 14 .9% (P<0 .0 1)以外 ,微量元素 Zn和 Fe分别下降 15 .2 % (P<0 .0 1)和 35 .1% (P<0 .0 1) ,Mo和 Cr分别下降 12 .2 % (P>0 .0 5 )和 14 .0 % (P>0 .0 5 ) ,而 Mn、Cu和 Co则无明显改变 ;Mg、Mn和 Zn等元素含量与 Ca、P经一元回归分析具有显著的相关性。结论 :去卵巢骨质疏松症模型大鼠骨骼 Ca、P、Mg、Zn和 Fe等含量明显下降。
Objective: To observe the changes of bone element contents in osteoporosis and their interrelationship. Methods: Twelve female SD rats, 10 month old, were bilaterally ovariectomized (OVX group) and another ten rats were received sham operation under anesthesia (SHAM group). The element contents in tibia, including Ca, P, Mg, Zn, Mn, Fe, Cu, Co, Mo and Cr, were determined by atomic absorption spectrophotometer 7 month later. The data of contents of all elements were analyzed by simple regression. Results: Compared with the SHAM group rats, the contents of Ca, P and Mg were decreased by 6.6%( P <0.05), 6.3%( P <0.05) and 14.9%( P <0.01) respectively. The contents of Zn and Fe were reduced by 15.2%( P <0.01) and 35.1%( P < 0.01 ) separately, Mo and Cr were decreased by 12.2%( P >0.05) and 14.0%( P >0.05), while the contents of Mn, Cu and Co were shown no change. There was a significant correlation among the contents of Mg,Mn,Zn,Ca and P. Conclusion: The contents of Ca,P,Mg,Zn and Fe were markedly reduced in bone of osteoporotic rats induced by ovariectomy.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2002年第3期185-188,共4页
Journal of Zhejiang University(Medical Sciences)
基金
浙江省自然科学基金 (3990 37)
关键词
骨质疏松
大鼠
胫骨
钙
磷
锰
锌
铁
动物疾病模型
微量元素
Osteoporosis
Element
Calcium
Phosphorus
Manganese
Zinc
Iron
Disease models,animal
Rat
