摘要
本文着重探讨了骨折后细胞免疫功能的变化及其与合并化脓性感染的关系。实验用家犬25条,其中对照组10条,实验组15条,检测了股骨骨折后皮肤迟发性过敏反应、淋巴细胞转化及白细胞移动抑制指数,结果发现骨折后1～7dDNCB皮肤迟发性过敏反应明显降低,淋巴细胞转化cpm及白细胞移动抑制指数显著下降。无感染者细胞免疫功能于骨折后2周恢复,合并化脓性骨髓炎者,直至骨折后30d仍来恢复至骨折前水平。骨折早期,细胞免疫功能显著降低,持续的细胞免疫功能受抑制引起机体对细菌的易感性增高,提示细胞免疫指标可作为防治骨折合并感染的监测指标供临床参考。
To evaluate the changes of cellular immunity and relationship between cellular immunosuppression and infection after fracture, we, examined delayed hypersensitivity response, lymphocyte transformation and leucocyte migration inhibition index in 25 dogs.It was found that delayed hypersensitivity response to DNCB,, lymphocyte transformation to phytohemagglutinin and leucocyte migration inhibition index were significant- ly decreased l to 7 d after fracture in comparison with the control before fracture.The function of cellular immunity was restored two weeks later in the uninfected dogs, but it was not restored in dogs with osteomyelitis even 30 d after fracture.The results suggest that traumatic fracture can impair host cellular immunity.Continual cellular immunosuppression renders the host more susceptible for bacteria and results in infectious complications.Cellular immune indices can be used as valuable ones to pievent and reat infectious complications post-fracture.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第4期357-359,共3页
Academic Journal of Second Military Medical University
关键词
骨折
细胞免疫
动物疾病模型
fracture
cellular immunity
disease models,animal
