摘要
合成了3个取代四苯基卟啉与5-氟脲嘧啶以共价相连的化合物。通过用它们加光照对小鼠移植瘤生长的抑制作用、对小鼠癌细胞的杀伤效果及对小鼠耳指数的测定,初步结果显示,化合物1,2,3对癌细胞都有光敏毒杀效应,但1远较2和3显著。
Three covalently linked porphyrin- fluorouracil compounds were synthesized. Measurement using these compounds for inhibition of mice transplanted tumor growth, cytotoxicity to mice cancer cells and the mice ear index under exposure to a light was performed. The results indicated that all these compounds were phototoxic to the cancer cells, and compound 1 was the most effective among them.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第6期415-419,共5页
Acta Pharmaceutica Sinica
关键词
卟啉
光敏效应
光动力学作用
Porphyrin
Photosensitive effect
Photodynamic action
