摘要
叶卟啉衍生物(Chloroporphyrin deriva-tive,CPD_4)20mg·L^(-1)合并照光5min,产生显著光溶血。CPD_410ng·L^(-1)加光照10_(min),小鼠红细胞膜乙酰胆碱酯酶(AchEs)明显失活,CP_420mg·L^(-1)加光照10min,小鼠肝线粒体ATP酶和肝微粒体G—6—P酶显著受抑,CPD_410mg·L^(-1)加光照10min,小鼠红细胞膜脂质过氧化产物丙二醛(MDA)大大增加,CPD_4受光照激发后产生超氧阴离子自由基O_2 产量与CPD_4剂量和光照时间有关。
Chloroporphyrin derivative (CPD1) 20mg · L-1 plus light 5min caused marked photohemolyses, At the dose of 10mg · L-1 20mg · L-1 plus light
10min. the activities of AchEs in red cell membane and ATPase in liver mitochondria and G-6-Plus in liver microsome were markedly inhibited lipid peroxida- tion of red cell membrane was greatly enhanced by CPD1 plus light when CPD1 was irrad - iated the production of free radical of superoxide anion was initiated the amount of O2 production was depen-
dent on CPD1 doses and irradiation time.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1992年第5期350-353,共4页
Chinese Pharmacological Bulletin
关键词
叶卟啉衍生物
光敏效应
质膜
chloroporphyrin deri -vative
photodynamic action
cell membrane.
