摘要
青蒿琥酯(artesunate,AS)是抗疟新药青蒿素的一个活性衍生物。近年来我国兽医工作者将其用于治疗牛羊泰勒氏焦虫病及双芽、巴贝斯焦虫病、鸡球虫病和耕牛血吸虫病,也收到了满意的效果。AS在大白鼠、兔、狗及人体内的药代动力学研究已见报道。
The pharmacokinetics of artesunate (AS)was studied in 3 cows, single dose of AS (5mg/kg) were administered intravenously and the drug concentrations were determined by means of a TLC method developed in our laberatory, The plasma drug concentration-time course of AS, after the treatment with a pharmacokinetic microcomputer program MCPKP edited by Wen-Jiang Xia, was found to be best fitted to a two compartment open model and its pharmacokinetic parameters were as follows, T_(1/2)α=2.43 min, T_(1/2)β=31.45 min, V_1=0.124 L/kg, V_B=0.937L/kg, Cl_B=0.0215 L/kg. min, AUC=236mg/L·min. Dihydroartemisinine (DHA), the main active metabolite of AS in the bodies, was detected simultaneously. Peak plasma concentration of 3.5μg/ml of DHA was reached at about 3 minutes after dosing and the AUC was 82 mg/L·min.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第3期225-227,共3页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
青蒿琥酯
药代动力学
代谢
Artesunate
Dihydroartemisinine
Pharmacokinetics
