摘要
目的：了解恶性疟原虫对各种常用抗疟药的敏感性，以指导合理应用抗疟药。方法：采用ＷＨＯ标准体外微量法。结果：甲氟喹和奎宁分别测定３６例和３３例，未发现抗性病例。氯喹、氨酚喹和哌喹抗性率分别为８４．６％、８６．１％和３８．０％。有８．３％病例对咯萘啶有抗性，少数病例对青蒿素类药物敏感性下降。结论：云南和海南两省恶性疟原虫对氯喹、氨酚喹和哌喹有高度抗性，但停用氯喹后，恶性疟原虫对氯喹敏感性有所恢复。对哌喹抗性率和抗性程度呈现逐渐上升趋势。对咯萘啶和青蒿素类药物的敏感性在逐渐降低。上述抗疟药抗性之间有一定交叉关系。
AIM: To assess the sensitivity of Plasmodium falciparum to antimalarials. METHOD: WHO standard in vitro microtest was used. RESULTS: Except for the absence of resistance to mefloquine and quinine, the resistance rate of the parasite to chloroquine, amodiaquine and piperaquine was 84 6%, 86 1% and 38 0% respectively. Plasmodium falciparum in 8 3% of the cases showed resistance to pyronaridine. CONCLUSION: Among the antimalarials tested in Hainan and Yunnan, high resistance of P.falciparum to chloroquine, amodiaquine and piperaquine was found. The sensitivity of P.falciparum in a few cases to pyronaridine and artemisinin and its derivatives was decreased. Cross resistance between some of the antimalarials has been evidenced.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
1996年第1期37-41,共5页
Chinese Journal of Parasitology and Parasitic Diseases
关键词
恶性疟原虫
抗药性
敏感性
氯喹
抗疟药
疟疾
Plasmodium falciparum, resistance, sensitivity, chloroquine, amodiaquine, piperaquine, pyronaridine, artemisinin and its derivatives
