摘要
棉酚是棉子中的一种色素,具有广泛生理活性。棉酚、醋酸棉酚、甲酸棉酚曾初步试用于男性节育,但有一定毒副作用,影响了临床进一步试用。目前国内外学者仍在进一步研究。棉酚的结构式如下:
The polymorphism of gossypol has been investigated by IR spectrophotometry and X-ray diffraction. Nine samples of gossypol crystallized from mixed solvent of ether, ethanol andwater (1:2:2), five samples from chloroform and ten samples from petroleum ether (bp 60～90℃) were determined. Significant differences in the infrared spectra of gossypol crystallized from three solvents were observed near 3500cm^(-1). The spectrum of gossypol crystallized from mixed solvent of ether, ethanol and water (mp 183～184℃) showed bands at 3500 (sh), 3470, 3375cm^(-1); that from chloroform (mp 198～199℃) at 3455, 3415(sh)cm^(-1) and that from petroleum ether (mp213～214℃) at 3510, 3495, 3430(sh), 3410cm^(-1). Moreover, the spectra of the three forms of gossypol showed slightly different bands at 780 and 600～400cm^(-1).Gossypol crystallized from the three solvents showed the same infrared spectra after being crystallized from acetone.Significant differences in the X-ray diffraction pattern of gossypol crystallized from the three solvents were also observed. Angles, intensities and D-values of most of the X-ray diffraction peaks were listed.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第2期152-155,共4页
Acta Pharmaceutica Sinica
关键词
棉酚
光谱法
衍射法
多晶型
Gossypol
Polymorphism
Infrared spectrophotometry
X-ray diffraction
