摘要
目的探讨快速减压对豚鼠脑组织中前列腺素的影响。方法将豚鼠分为快速减压组和对照组 ,快速减压组动物置于小加压舱内 ,5min加压至 0 .6MPa,并在该压力下暴露 60min ,用 1 9min减压至常压出舱 ;对照组不进行加减压处理。在实验结束时处死动物取脑皮质 ,用酶免测定法测定组织中前列腺素E2 (PGE2 ) ,血栓素B2 (TXB2 )和 6-酮 -前列腺素F1a( 6 K PGF1a)含量。结果快速减压后 ,脑皮质中的PGE2 为对照组的 2倍 ,TXB2 为对照组的 3倍 ,6 K PGF1a为对照组的 2 .6倍 ,3种PGs与对照组比均有非常显著性差异 (P <0 .0 1 )。结论快速减压可引起机体脑组织中不同前列腺素含量明显升高 。
Objective To investigate the effect of fast decompression on prostaglandins in cerebral tissue. Method 26 guinea pigs were divided into 2 groups randomly.The animals in group FDC(group 1) were treated with fast decompression and formed decompression sickness, but those in control group(group 2) were not treated with decompression. The contents of prostaglandin E 2 (PGE 2)?6 keto prostaglandin F 1a (6 K PGF 1a ) and thromboxane B 2 (TXB 2) in cerebral tissue of the animals were determined by enzyme immunoassay. Result The content of PGE 2 in cerebral tissue of FDC animals was twice as much as that in control animals. The content of TXB 2 in cerebral tissue of FDC animals was 3 times as high as that in control animals, and that of 6 K PGF 1a in cerebral tissue of FDC animals was 2.6 times as that in control animals. It showed very significant differences as compared with control group(P<0.01). Conclusion The content of PGs in cerebral tissue increased markedly after fast decompression,and may cause cerebral injury.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2002年第3期212-213,共2页
Space Medicine & Medical Engineering
基金
总后卫生部科研基金资助课题 ( 96L0 0 3)
关键词
快速减压
豚鼠
脑组织
前列腺素
前列腺素E2
血栓素B2
fast decompression
cerebral tissue
prostaglandin E 2
thromboxane B 2
6 keto prostaglandin F 1a
guinea pigs
