摘要
目的 :探讨动物处于减压病 (DCS)临界发病状态时微循环及其血流动力作用的改变。方法 :采用小型化激光微循环综合参数测量仪及LDF 3微区血流量仪 ,以检测动物高压暴露前及快速减压后微循环和血流动力作用的改变。结果 :快速减压后动物微血管明显收缩 ;毛细血管开放数量减少 ;微循环中可见气泡并有血栓形成 ;白细胞、血小板与血管内皮细胞粘附 ;血流中有较多白色微小血栓 ;细动脉血流速度平均比正常状态减慢 0 .9mm/s,细静脉流速减慢 0 .7mm/s,脑血流量可下降 5 0 %以上 (P <0 .0 1)。结论 :快速减压后溶解在体内的惰性气体不能进行安全脱饱和 ,引起机体超强应激反应和损伤 ,使微循环血流动力作用紊乱 ,造成组织缺血、缺氧 ,并在体内形成了气泡。
Aim:Changes of microcirculation and hemodynamics were probed during critical decompression sickness (DCS) in animals. Methods: Small laser microcirculatory synthetical parameter meter and LDF-3 laser doppler flowmeter were used in the experiment, the changes of microcirculation and hemodynamics were measured before hyperbaric exposure and after fast decompression in animals. Results: After fast decompression in animals, microvessels constracted, open number of capillary reduced, air bubbles occurred and thrombi formed in microcirculation, leukocytes and platelets adhered to endothelial cells. There were many white microthrombi in the blood now. Average blood flow rate of arteriole decreased 0.9 mm/s, venulae decreased 0.7 mm/s, cerebral volume of blood fiow droped 50% or over as compared with the control group( P <0.01). Conclution: After fast decompression, inert gas dissolved in body could not be inability safety desaturation, result in a powerfull stress reaction and injury in the body. Microcircutory homodynmics disorder, ischemia and hypoxia occurred in tissue and air bubbles formed.
出处
《中国应用生理学杂志》
CAS
CSCD
2000年第3期202-205,共4页
Chinese Journal of Applied Physiology
基金
总后卫生部科研基金!资助课题 (96L0 0 3)
关键词
减压病
微循环
气栓
内皮细胞
应激
大脑血流量
decompression sickness
microcirculation
air bubble
endothelial cell
stress
