摘要
目的观察诺维本(NVB)、异环磷酰胺(IFO)联合顺铂(DDP)方案与长春花碱酰氨(VDS)、丝裂霉素(MMC)联合顺铂(DDP)方案治疗老年非小细胞肺癌的疗效。方法94例随机分为二组。46例NIP方案用NVB25mg/m2静滴,d1～d8;IFO1.2g/m23h静滴d1～d3;MESNA400mg4h静推,d1～d3;DDP100mg/m2,d1静滴;配合水化、利尿、止吐,每4周为一期,共3期。48例MVP方案用VDS3mg/m2静注d1、d8;MMC10mg/m2d1;DDP100mg/m2静滴d1;配合水化、利尿、止吐,每4周为一期,共3期。结果NIP与MVP组有效率分别为45.6%与41.6%,中位生存期分别为10.2月和9.8月,一年生存率分别为28.9%与26.7%,两者无显著性差异(P>0.05)。毒副反应以骨髓抑制、消化道反应及局部静脉炎为主;均无肝脏损害等毒性反应发生。NIP组白细胞下降较MVP组明显,消化道反应则反之(P<0.05)。结论治疗老年非小细胞肺癌,本文两个方案均能获一定缓解。两组疗效相仿,均较安全。但MVP方案较经济更适于推广。
Objective To evaluate clinical efficacy of NIP (NVB、IFO、DDP) and MVP (MMC、VDS、DDP) combined chemotherapy in senile patients with non-small cell lung cancers. Methods Ninety four cases were divided into two groups at random.46 patients received NIP regimen, with NVB 25mg/m2 by i.v. infusion at the lst and 8th day,IFO 1.2g/m2,by i.v.infusion from lst to 3rd day;MESNA 400mg,by i.v.injection from 1st to 3rd day; and DDP 100mg/m2 by i.v.infusion only at the lst day. Accessory treatment such as hydration, diuretic and antiemetic was given simultaneously. 48 patients received another chemotherapy regimen with VDS 3mg/m2 by i.v.injection at the lst and 8th day,MMC 10mg/m2 and DDP 100mg/m2 by i.v. infusion at the lst day. Hydration treatment was also used in this group. The regimens were repeated every 4 weeks for 3 times. Results The effective rate in INP and MVP group was 45.6% and 41.6% respectively; median survival periods,10.2, and 9.8 months;and one year survival rate, 28.9% and 26.7%. No statistical difference was observed (P >0.05). Chemotoxic and adverse effects of antitumor drugs such as bone marrow suppression, gastrointestinal symptoms and local phlebitis were noticed in both groups, liver damage was not seen. Leucopenia in NIP group was more obvious than that in MVP group, and gastrointestinal symptoms were more severe in MVP group(P< 0.05) . Conclusions NIP and MVP combined chemotherapy brought some remission in senile patients with non-small cell lung cancers. The clinical efficacy of two regimens was similar, with low toxicity and relative safety.However MVP regimen was more economic and easy to be popularized.
出处
《老年医学与保健》
CAS
2002年第2期92-94,共3页
Geriatrics & Health Care
