摘要
目的 :观察诺维本 (NVB)、异环磷酰胺 (IFO)、顺铂 (PDD)三药联合 (NIP方案 )治疗晚期非小细胞肺癌的疗效和毒性。方法 :应用NIP方案治疗ⅢB、Ⅳ期非小细胞肺癌 98例 ,NVB 2 5mg m2 ,静脉滴入 ,第 1、8天 ;IFO 1.5g m2 ,静脉滴入 ,第 1～ 3天 ;PDD 30mg m2 ,静脉滴入 ,第 1～ 3天 ;4周为 1个周期。结果 :CR 1例 ,PR 4 4例 ,NC 4 5例和PD 8例 ,总有效率 (CR +PR)为 4 5 .1%。中位缓解期 8个月 ,中位生存期 11个月 ,1年生存率为 4 8%。骨髓抑制为剂量限制性毒性 ,其中Ⅲ～Ⅳ度占 4 0 .8%。结论 :NIP方案是治疗晚期非小细胞肺癌有效且安全的方案。
Objective To evaluate the efficacy and toxicity of combination chemotherapy of navelbine(NVB)?ifosfamide(IFO)and cisplatin(PDD) in the treatment of advanced non small cell lung cancer (NSCLC).Methods Ninety eight patients with advanced NSCLC were treated.Histological distrbution included 51 squamous cell carcinomas,42 adenocarcinomas and 5 large cell carcinomas.Stage distribution was 59 stage Ⅲ B and 39 stage Ⅳ.Seventy one patients had no prior chemotherapy and 27 were previously treated.The chemotherapy regimen consisted of NVB 25 mg/m 2 on days 1 and 8,IFO 1.5 g/m 2 and PDD 30 mg/m 2 on days 1-3 every 4 weeks.Results The overall response rate was 45.9% with 1 complete responses(1.0%) and 44(44.9%) partial responses.The median time to progression was 8 months.The median survival 11 months.One year survival was 48%.The dose limiting toxicity was leukopenia with grades Ⅲ～Ⅳ in 40.8%.Conclusion NIP is active and safe in advanced NSCLC.It should be warrant for further study.
出处
《肿瘤防治杂志》
2001年第5期504-505,共2页
China Journal of Cancer Prevention and Treatment
