摘要
周围神经药物注射伤病变发生早,变化快,损伤重。青霉素等四种药物注入兔腓神经后1小时即可出现神经纤维水肿,局部脱髓鞘,轴突轻度皱缩。6小时部分髓鞘破碎,轴突裸露,皱缩明显,线粒体肿胀,嵴变短,轴浆内微丝、微管减少。24小时髓鞘、轴突大部分破碎,轴突内可见大量髓样小体,线粒体肿胀加重,嵴消失,雪旺氏细胞核内物质凝集呈颗粒状。电生理检查发现,在损伤早期,传导速度改变可不明显,但动作电位波幅急剧下降为共有特征。
In 50 animals, 100 nerve injections were carried out by using four drugs and the physiological saline was used as control. The pathological alterations in the nerve were evident as early as 1 hour after injection with splitting of the myelin larnellae in local areas. At 24 hours, there were areas of complete delamination and fragmentetion of the myelin sheath. Some axons had completely disintegreted. A remarkable reduction in the amplitude of nerve-muscle action potentials was indicative of early ncurophysiological changes in this type of nerve injury and the detection of this was conducive to its early diagnosis.
出处
《修复重建外科杂志》
CSCD
1991年第4期232-234,共3页
Chinese Journal of Reparative and Reconstructive Surgery
