摘要
目的:评价和比较NVB和放疗同步与序贯治疗局部晚期NSCLC近期疗效和患者耐受性。方法:41例晚期NSCLC患者随机分入同步治疗组和序贯治疗组。同步组每周前3日放疗前予NVB加DDP化疗,共6周。序贯组予2周期NP方案(NVB 25mg/m^(2),d1、8,DDP50mg,d1-3)化疗后常规放疗。结果:同步组和序贯组总有效率分别为667%和50%,差异无显著性。同步组局部控制率高于序贯组(P<005)。两组不良反应无显著性差异。结论:NVB加DDP和放疗同步治疗晚期NSCLC局部控制率高于序贯治疗,总有效率及不良反应两组相近。
Objective:To study the response and tolerance to concomitant and sequential chemo-radiotherapy with NVB plus DDP in locally advanced NSCLC.Methods:41 patients with advanced NSCLC were divided into synchronous group and sequential group randomly.Synchronous group:21 patients received conventional radiotherapy daily,before radiotherapy NVB and DDP was given for 3 days a week,totally 6 weeks.Sequential group:20 patients received radiotherapy as same as synchronous group after a cycles chemotherapy with NP regimen(NVB 25 mg/m^(2),d1,8,DDP 50 mg,d1-3).Results:The effective rates of synchronous and sequential group was 66.7%and 50%,respectively(P>0.05).The local control rate of synchronous group was significantly higher than sequential group(P<0.05).There was no significant difference between two groups in the side effects.Conclusion:Concommtant and sequential chemoradiotherapy with NVB plus DDP has similar effective rate and side effects rates,while synchronous treatment has a higher local control rates.
作者
曾凡玉
袁峰
Zeng Fanyu;Yuan Feng(Department of Radiation Oncology,Hubei Cancer Hospital,Wuhan 430079)
出处
《临床肿瘤学杂志》
CAS
2002年第3期222-223,共2页
Chinese Clinical Oncology
关键词
非小细胞肺癌
放化疗
同步
序贯
盖诺
Non Small Cell Lung Cancer
Chemo-radiotherapy concomitant therapy
Sequential therapy
Navelbine
