摘要
目的探讨局部晚期非小细胞肺癌(NSCLS)行放化疗治疗的预后情况及其相关影响因素。方法回顾性分析2014年1月至2015年4月在我院行放化疗治疗局部晚期NSCLS患者90例临床资料,行放化疗综合治疗或单纯放疗,分析局部晚期NSCLS行放化疗治疗预后相关影响因素。结果90例患者治疗总有效率为64.44%(58/90),单纯放疗、序贯放化疗、同步放化疗治疗总有效率分别为23.33%(7/20)、64.52%(20/31)、79.48%(31/39);1年、3年、5年生存率分别为78.89%(71/90)、32.22%(29/90)、25.56%(23/90);Logistic回归分析显示,性别、KPS评分<80分、临床分期ⅢB期、近期疗效PR、联合放化疗是局部晚期NSCLS行放化疗治疗后生存率的的独立危险因素(P<0.05且OR≥1)。结论同步放化疗方案治疗局部晚期NSCLS疗效较好,临床需加以重视。
Objective To investigate the prognosis of radiotherapy and chemotherapy in locally advanced non-small cell lung cancer(NSCLS)and its related influencing factors.Methods A retrospective analysis was performed on 90 clinical data of patients with locally advanced NSCLS who underwent radiotherapy and chemotherapy in our hospital from January 2014 to April 2015.Comprehensive radiotherapy and chemotherapy or radiotherapy alone were performed.analysis of influential factors on prognosis of radiotherapy and chemotherapy for locally advanced NSCLS.Results The total effective rate of treatment in 90 patients was 64.44%(58/90).The total effective rates of radiotherapy alone,sequential radiochemotherapy,and concurrent radiochemotherapy were 23.33%(7/20),64.52%(20/31),79.48%(31/39);1-,3-,and 5-year survival rates were 78.89%(71/90),32.22%(29/90),and 25.56%(23/90);Logistic regression analysis showed that gender,KPS score<80,clinical stageⅢB,short-term efficacy PR,combined with radiotherapy and chemotherapy are independent risk factors for survival rate of radiotherapy and chemotherapy in locally advanced NSCLS(P<0.05 and OR≥1).Conclusion Concurrent chemoradiotherapy is effective in treating locally advanced NSCLS,Factors that need to be taken seriously clinically.
作者
张英
李杨
ZHANG Ying;LI Yang(Department of Oncology,Shangqiu First People's Hospital,Shangqiu476100 China)
出处
《内蒙古医学杂志》
2020年第7期774-776,共3页
Inner Mongolia Medical Journal
基金
河南省医学科技攻关计划项目(编号:2015B063508)
关键词
非小细胞肺癌
放化疗
locally advanced non-small cell lung cancer
radiotherapy and chemotherapy
