摘要
目的 探讨化疗药物对机体免疫系统是否存在不同程度的抑制作用。方法 32例恶性实体肿瘤患者 1个周期化疗前后分别对细胞因子 :IL 2、IL 18、TNF α进行了测定。结果 IL 2、I 18在化疗前后变化不显著 ,P>0 0 5。而TNF α在化疗后期有明显下降 ,P <0 0 5。结论 机体的细胞免疫系统在化疗药物细胞毒性物质作用下能够发挥较强的自我调节能力 ,维持自身水平于一定的稳定状态 。
Objective To investigate the effect of chemotherapy drugs on the immune system.Methods This paper inspected cellular immune responsive ability before and after chemotherapy in 32 malignant solid tumor patients.Cytokines like IL 2,IL 18 and TNF α were measured,and the mechanisms of specific index change was studied.Results The experiment showed that levels of IL 2,IL 18 which represented cellular immunity indirectly did not have significant difference at the early and later stage of chemotherapy,P>0 05.Only the level of TNF α decreased obviously at the later stage of chemotherapy,P<0 05.Conclusions This shows that organic immune system has a higher self regulated ability when affected by cytotoxic substance chemotherapy in order to maintain sable to some degree and perform its immunity function well.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2002年第6期352-353,共2页
Chinese Journal of Practical Internal Medicine
